Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors

Wedi'i Gadw mewn:

Manylion Llyfryddiaeth
Cyhoeddwyd yn:	Journal of Applied Physiology vol. 117, no. 4 (Aug 15, 2014), p. 345
Prif Awdur:	Green, Daniel J
Awduron Eraill:	Eijsvogels, Thijs, Bouts, Yvette M, Maiorana, Andrew J, Naylor, Louise H, Scholten, Ralph R, Spaanderman, Marc E A, Pugh, Christopher J A, Sprung, Victoria S, Schreuder, Tim, Jones, Helen, Cable, Tim, Hopman, Maria T E, Thijssen, Dick H J
Cyhoeddwyd:	American Physiological Society
Pynciau:	Exercise Veins & arteries Cardiovascular disease Risk factors Regression analysis Body mass index Cholesterol Physical training Body weight Health risks Social
Mynediad Ar-lein:	Citation/Abstract
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Disgrifiad
Crynodeb:	The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type exercise training interventions with pre-/posttraining measures of flow-mediated dilation (FMD%) to assess artery function. All studies adopted an identical FMD protocol (5-min ischemia, distal cuff inflation), contemporary echo-Doppler methodology, and observer-independent automated analysis. Linear regression analysis was used to identify factors contributing to changes in FMD%. We found that cardiopulmonary fitness improved, and weight, body mass index (BMI), cholesterol, and mean arterial pressure (MAP) decreased after training, while FMD% increased in 76% of subjects (P < 0.001). Training-induced increase in FMD% was predicted by lower body weight (β = -0.212), lower baseline FMD% (β = -0.469), lower training frequency (β = -0.256), and longer training duration (β = 0.367) (combined: P < 0.001, r = 0.63). With the exception of a modest correlation with total cholesterol (r = -0.243, P < 0.01), changes in traditional cardiovascular risk factors were not significantly related to changes in FMD% (P > 0.05). In conclusion, we found that, while some subjects do not demonstrate increases following exercise training, improvement in FMD% is present in those with lower pretraining body weight and endothelial function. Moreover, exercise training-induced change in FMD% did not correlate with changes in traditional cardiovascular risk factors, indicating that some cardioprotective effects of exercise training are independent of improvement in risk factors.
ISSN:	8750-7587 1522-1601 0021-8987 0161-7567
Ffynhonnell:	Biological Science Database