Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus
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| Հրատարակված է: | Scientific Reports (Nature Publisher Group) vol. 8 (Jul 2018), p. 1 |
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| Հիմնական հեղինակ: | |
| Այլ հեղինակներ: | , , , , , , , , , , , , , |
| Հրապարակվել է: |
Nature Publishing Group
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| Խորագրեր: | |
| Առցանց հասանելիություն: | Citation/Abstract Full Text - PDF |
| Ցուցիչներ: |
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| 024 | 7 | |a 10.1038/s41598-018-28234-y |2 doi | |
| 035 | |a 2064743330 | ||
| 045 | 2 | |b d20180701 |b d20180731 | |
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| 100 | 1 | |a Bordet, Elise |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 245 | 1 | |a Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus | |
| 260 | |b Nature Publishing Group |c Jul 2018 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed that AM-like cells are macrophages phagocytosing blood-borne particles, in agreement with a pulmonary intravascular macrophages (PIM) identity. PIM have been described microscopically long time ago in species from the Laurasiatheria superorder such as bovine, swine, cats or cetaceans. We observed that PIM were more inflammatory than AM upon infection with the porcine reproductive and respiratory syndrome virus (PRRSV), a major swine pathogen. Moreover, whereas PRRSV was thought to mainly target AM, we observed that PIM were a major producer of virus. The PIM infection was more correlated with viremia in vivo than AM infection. Finally like AM, PIM-expressed genes were characteristic of an embryonic monocyte-derived macrophage population, whose turnover is independent of bone marrow-derived hematopoietic precursors. This last observation raised the interesting possibility that AM and PIM originate from the same lung precursor. | |
| 653 | |a Infections | ||
| 653 | |a Embryos | ||
| 653 | |a Monocytes | ||
| 653 | |a Bone turnover | ||
| 653 | |a Hemopoiesis | ||
| 653 | |a Osteoprogenitor cells | ||
| 653 | |a Leukocytes (mononuclear) | ||
| 653 | |a Viremia | ||
| 653 | |a Macrophages | ||
| 653 | |a Phagocytes | ||
| 653 | |a Bone marrow | ||
| 653 | |a Inflammation | ||
| 653 | |a Respiratory diseases | ||
| 653 | |a Lungs | ||
| 653 | |a Swine | ||
| 700 | 1 | |a Maisonnasse, Pauline |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Renson, Patricia |u Anses, Laboratoire de Ploufragan-Plouzane, Unité Virologie et Immunologie Porcines, Ploufragan, France; Université Bretagne Loire, Cité internationale, Rennes, France; Union des Groupements de Producteurs de Viande de Bretagne (UGPVB), Rennes, cedex, France | |
| 700 | 1 | |a Bouguyon, Edwige |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Crisci, Elisa |u Génétique Animale et Biologie, Intégrative (GABI) UMR 1313, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA | |
| 700 | 1 | |a Tiret, Mathieu |u Génétique Animale et Biologie, Intégrative (GABI) UMR 1313, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Descamps, Delphyne |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Bernelin-Cottet, Cindy |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Urien, Céline |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Lefèvre, François |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Jouneau, Luc |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Bourry, Olivier |u Anses, Laboratoire de Ploufragan-Plouzane, Unité Virologie et Immunologie Porcines, Ploufragan, France; Université Bretagne Loire, Cité internationale, Rennes, France | |
| 700 | 1 | |a Jean-Jacques Leplat |u Génétique Animale et Biologie, Intégrative (GABI) UMR 1313, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Schwartz-Cornil, Isabelle |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 700 | 1 | |a Bertho, Nicolas |u Virologie et Immunologie Moléculaires UR892, Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy-en-Josas, France | |
| 773 | 0 | |t Scientific Reports (Nature Publisher Group) |g vol. 8 (Jul 2018), p. 1 | |
| 786 | 0 | |d ProQuest |t Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/2064743330/abstract/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/2064743330/fulltextPDF/embedded/ZKJTFFSVAI7CB62C?source=fedsrch |