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Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

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izdano v:Scientific Reports (Nature Publisher Group) vol. 8 (Jul 2018), p. 1
Glavni avtor: Bordet, Elise
Drugi avtorji: Maisonnasse, Pauline, Renson, Patricia, Bouguyon, Edwige, Crisci, Elisa, Tiret, Mathieu, Descamps, Delphyne, Bernelin-Cottet, Cindy, Urien, Céline, Lefèvre, François, Jouneau, Luc, Bourry, Olivier, Jean-Jacques Leplat, Schwartz-Cornil, Isabelle, Bertho, Nicolas
Izdano:
Nature Publishing Group
Teme:
Infections
Embryos
Monocytes
Bone turnover
Hemopoiesis
Osteoprogenitor cells
Leukocytes (mononuclear)
Viremia
Macrophages
Phagocytes
Bone marrow
Inflammation
Respiratory diseases
Lungs
Swine
Online dostop:Citation/Abstract
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Resumen:Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed that AM-like cells are macrophages phagocytosing blood-borne particles, in agreement with a pulmonary intravascular macrophages (PIM) identity. PIM have been described microscopically long time ago in species from the Laurasiatheria superorder such as bovine, swine, cats or cetaceans. We observed that PIM were more inflammatory than AM upon infection with the porcine reproductive and respiratory syndrome virus (PRRSV), a major swine pathogen. Moreover, whereas PRRSV was thought to mainly target AM, we observed that PIM were a major producer of virus. The PIM infection was more correlated with viremia in vivo than AM infection. Finally like AM, PIM-expressed genes were characteristic of an embryonic monocyte-derived macrophage population, whose turnover is independent of bone marrow-derived hematopoietic precursors. This last observation raised the interesting possibility that AM and PIM originate from the same lung precursor.
ISSN:2045-2322
DOI:10.1038/s41598-018-28234-y
Fuente:Science Database