Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas
I tiakina i:
| I whakaputaina i: | NPJ Regenerative Medicine vol. 9, no. 1 (2024), p. 11 |
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| Kaituhi matua: | |
| Ētahi atu kaituhi: | , , , , , , , , , , , , , , , , , , , |
| I whakaputaina: |
Nature Publishing Group
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| Ngā marau: | |
| Urunga tuihono: | Citation/Abstract Full Text - PDF |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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MARC
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| 022 | |a 2057-3995 | ||
| 024 | 7 | |a 10.1038/s41536-024-00355-1 |2 doi | |
| 035 | |a 2933664650 | ||
| 045 | 2 | |b d20240101 |b d20241231 | |
| 084 | |a 274872 |2 nlm | ||
| 100 | 1 | |a Simoliunas, Egidijus |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 245 | 1 | |a Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas | |
| 260 | |b Nature Publishing Group |c 2024 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness. We developed an injectable Cornea-in-a-Syringe (CIS) sealant-filler to treat damaged corneas. CIS comprises linear carboxylated polymers of inflammation-suppressing 2-methacryloyloxyethyl phosphorylcholine, regeneration-promoting collagen-like peptide, and adhesive collagen-citrate glue. We also incorporated GF19, a modified anti-viral host defense peptide that blocked HSV-1 activity in vitro when released from silica nanoparticles (SiNP-GF19). CIS alone suppressed inflammation when tested in a surgically perforated and HSV-1-infected rabbit corneal model, allowing tissue and nerve regeneration. However, at six months post-operation, only regenerated neocorneas previously treated with CIS with SiNP-GF19 had structural and functional features approaching those of normal healthy corneas and were HSV-1 virus-free. We showed that composite injectable biomaterials can be designed to allow regeneration by modulating inflammation and blocking viral activity in an infected tissue. Future iterations could be optimized for clinical application. | |
| 653 | |a Infections | ||
| 653 | |a Corneal transplantation | ||
| 653 | |a Collagen | ||
| 653 | |a Nanoparticles | ||
| 653 | |a Regenerative medicine | ||
| 653 | |a Polymerization | ||
| 653 | |a Herpes viruses | ||
| 653 | |a Hospitals | ||
| 653 | |a Amino acids | ||
| 653 | |a Inflammation | ||
| 653 | |a Peptides | ||
| 653 | |a Viral infections | ||
| 653 | |a Polyethylene glycol | ||
| 653 | |a Hydrogels | ||
| 653 | |a Antiviral drugs | ||
| 700 | 1 | |a Ruedas-Torres, Inés |u University of Córdoba, International Excellence Agrifood Campus ‘CeiA3’, Department of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Córdoba, Spain (GRID:grid.411901.c) (ISNI:0000 0001 2183 9102) | |
| 700 | 1 | |a Jiménez-Gómez, Yolanda |u Reina Sofia University Hospital and University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Cordoba, Spain (GRID:grid.411901.c) (ISNI:0000 0001 2183 9102) | |
| 700 | 1 | |a Edin, Elle |u University of Montreal, Department of Ophthalmology and Institute of Biomedical Engineering, Montrea, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2104 2136); Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada (GRID:grid.414216.4) (ISNI:0000 0001 0742 1666) | |
| 700 | 1 | |a Aghajanzadeh-Kiyaseh, Mozhgan |u University of Montreal, Department of Ophthalmology and Institute of Biomedical Engineering, Montrea, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2104 2136); Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada (GRID:grid.414216.4) (ISNI:0000 0001 0742 1666) | |
| 700 | 1 | |a Zamani-Roudbaraki, Mostafa |u University of Montreal, Department of Ophthalmology and Institute of Biomedical Engineering, Montrea, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2104 2136); Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada (GRID:grid.414216.4) (ISNI:0000 0001 0742 1666) | |
| 700 | 1 | |a Asoklis, Rimvydas |u Vilnius University Hospital, Department of Ophthalmology, Vilnius, Lithuania (GRID:grid.426597.b) (ISNI:0000 0004 0567 3159) | |
| 700 | 1 | |a Alksne, Milda |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 700 | 1 | |a Thathapudi, Neethi C. |u University of Montreal, Department of Ophthalmology and Institute of Biomedical Engineering, Montrea, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2104 2136); Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada (GRID:grid.414216.4) (ISNI:0000 0001 0742 1666) | |
| 700 | 1 | |a Poudel, Bijay K. |u University of Montreal, Department of Ophthalmology and Institute of Biomedical Engineering, Montrea, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2104 2136); Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada (GRID:grid.414216.4) (ISNI:0000 0001 0742 1666) | |
| 700 | 1 | |a Rinkunaite, Ieva |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 700 | 1 | |a Asoklis, Kasparas |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 700 | 1 | |a Iesmantaite, Monika |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 700 | 1 | |a Ortega-Llamas, Laura |u Reina Sofia University Hospital and University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Cordoba, Spain (GRID:grid.411901.c) (ISNI:0000 0001 2183 9102) | |
| 700 | 1 | |a Makselis, Almantas |u Vilnius University Hospital, Department of Ophthalmology, Vilnius, Lithuania (GRID:grid.426597.b) (ISNI:0000 0004 0567 3159) | |
| 700 | 1 | |a Munoz, Marcelo |u University of Ottawa, Heart Institute, Ottawa, Canada (GRID:grid.28046.38) (ISNI:0000 0001 2182 2255) | |
| 700 | 1 | |a Baltriukiene, Daiva |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 700 | 1 | |a Bukelskiene, Virginija |u Vilnius University, Department of Biological Models, Institute of Biochemistry, Life Sciences Center, Vilnius, Lithuania (GRID:grid.6441.7) (ISNI:0000 0001 2243 2806) | |
| 700 | 1 | |a Gómez-Laguna, Jaime |u University of Córdoba, International Excellence Agrifood Campus ‘CeiA3’, Department of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group (UCO-PIG), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Córdoba, Spain (GRID:grid.411901.c) (ISNI:0000 0001 2183 9102) | |
| 700 | 1 | |a González-Andrades, Miguel |u Reina Sofia University Hospital and University of Cordoba, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Cordoba, Spain (GRID:grid.411901.c) (ISNI:0000 0001 2183 9102) | |
| 700 | 1 | |a Griffith, May |u University of Montreal, Department of Ophthalmology and Institute of Biomedical Engineering, Montrea, Canada (GRID:grid.14848.31) (ISNI:0000 0001 2104 2136); Maisonneuve-Rosemont Hospital Research Centre, Montreal, Canada (GRID:grid.414216.4) (ISNI:0000 0001 0742 1666) | |
| 773 | 0 | |t NPJ Regenerative Medicine |g vol. 9, no. 1 (2024), p. 11 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/2933664650/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/2933664650/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |