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Evaluation of Antimicrobial Properties, Cell Viability, and Metalloproteinase Activity of Bioceramic Endodontic Materials Used in Vital Pulp Therapy

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Wydane w:Journal of Functional Biomaterials vol. 15, no. 3 (2024), p. 70
1. autor: Immich, Felipe
Kolejni autorzy: Durvalino de Oliveira, Juliana Silva Ribeiro de Andrade, Andressa da Silva Barboza, Cuevas-Suárez, Carlos Enrique, Adriana Fernandes da Silva, Wellington Luiz de Oliveira da Rosa, Borges, Álvaro Henrique, Neftali Lenin Villarreal Carreno, Piva, Evandro, Rafael Guerra Lund
Wydane:
MDPI AG
Hasła przedmiotowe:
Brasseler USA
Brazil
Basel Switzerland
Switzerland
United States > US
Cytotoxicity
Endodontics
Silicones
Biofilms
Extracellular matrix
Matrix metalloproteinases
Radiation
Cell culture
Fibroblasts
Metalloproteinase
Bioceramics
Antimicrobial agents
Electrophoresis
Dental pulp
Matrix metalloproteinase
Dentistry
Cement
Cell viability
Enzymes
Variance analysis
Environmental
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Streszczenie:This study aimed to evaluate the antimicrobial properties, cell viability, and matrix metalloproteinase (MMP) inhibition capacity of several endodontic materials aimed at vital pulp therapy: Pro Root MTA®, EndoSequence®, Biodentine®, MTA Angelus®, TheraCal LC®, and BioC Repair®. The materials were prepared according to the manufacturer’s instructions. Antimicrobial tests were conducted using a microcosm biofilm model, cell viability was assessed using murine fibroblasts (L929), and MMP activity was analyzed through electrophoresis. The results showed that BioC Repair®, Biodentine®, and EndoSequence® exhibited similar antimicrobial properties, while MTA Angelus® and ProRoot MTA® had inferior results but were comparable to each other. In terms of cell viability, no significant differences were observed among the materials. EndoSequence® demonstrated the highest MMP inhibition capacity. In conclusion, BioC Repair®, Biodentine®, EndoSequence®, and TheraCal® showed better antimicrobial properties among the tested materials. The materials did not exhibit significant differences in terms of cytotoxicity. However, EndoSequence® displayed superior MMP inhibition capacity.
ISSN:2079-4983
DOI:10.3390/jfb15030070
Źródło:Materials Science Database