microRNA Profile of High-Grade B-Cell Lymphoma with 11q Aberration
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| Publicado en: | International Journal of Molecular Sciences vol. 26, no. 1 (2025), p. 285 |
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| Otros Autores: | , , , , , , , , , , , , , |
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| 024 | 7 | |a 10.3390/ijms26010285 |2 doi | |
| 035 | |a 3153751745 | ||
| 045 | 2 | |b d20250101 |b d20250114 | |
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| 100 | 1 | |a Zajdel, Michalina |u Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland<email>filip.hajdyla@nio.gov.pl</email> (F.H.); <email>magdalena.chechlinska@nio.gov.pl</email> (M.Ch.) | |
| 245 | 1 | |a microRNA Profile of High-Grade B-Cell Lymphoma with 11q Aberration | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare germi-nal centre lymphoma characterised by a typical gain/loss pattern on chromo-some 11q but without MYC translocation. It shares some features with Burkitt lymphoma (BL), HGBCLs and germinal centre-derived diffuse large B-cell lym-phoma, not otherwise specified (GCB-DLBCL-NOS). Since microRNA expression in HGBCL-11q remains unknown, we aimed to identify and compare the mi-croRNA expression profiles in HGBCL-11q, BL and in GCB-DLBCL-NOS. Next-generation sequencing (NGS)-based microRNA profiling of HGBCL-11q (n = 6), BL (n = 8), and GCB-DLBCL-NOS without (n = 3) and with MYC rearrange-ment (MYC-R) (n = 7) was performed. We identified sets of 39, 64, and 49 mi-croRNAs differentiating HGBCL-11q from BL, and from GCB-DLBCL-NOS without MYC-R, respectively. The expression levels of miR-223-3p, miR-193b-3p, miR-29b-3p, and miR-146a-5p consistently differentiated HGBCL-11q from both BL, GCB-DLBCL-NOS without MYC-R. In addition, HGBCL-11q presented greater heterogeneity in microRNA expression than BL. The expression profile of MYC-regulated microRNAs differed in HGBCL-11q and in BL, while also clearly distinguishing HGBCL-11q and BL from GCB-DLBCL-NOS. The microRNA pro-file of HGBCL-11q differs from those of BL and GCB-DLBCL-NOS, exhibiting greater heterogeneity compared to BL. The microRNA profile further supports that HGBCL-11q is a distinct subtype of B-cell lymphoma. | |
| 653 | |a MicroRNAs | ||
| 653 | |a Lymphoma | ||
| 653 | |a Morphology | ||
| 700 | 1 | |a Szafron, Łukasz Michał |u Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland; <email>lukszafron@gmail.com</email> (Ł.M.S.); | |
| 700 | 1 | |a Paziewska, Agnieszka |u Faculty of Medical and Health Sciences, Siedlce University, Konarskiego 2, 08-110 Siedlce, Poland | |
| 700 | 1 | |a Rymkiewicz, Grzegorz |u Flow Cytometry Laboratory, Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland | |
| 700 | 1 | |a Dąbrowska, Michalina |u Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland; <email>lukszafron@gmail.com</email> (Ł.M.S.); | |
| 700 | 1 | |a Bystydzieński, Zbigniew |u Flow Cytometry Laboratory, Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland | |
| 700 | 1 | |a Kulińczak, Mariusz |u Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland<email>filip.hajdyla@nio.gov.pl</email> (F.H.); <email>magdalena.chechlinska@nio.gov.pl</email> (M.Ch.) | |
| 700 | 1 | |a Grygalewicz, Beata |u Cytogentics Laboratory, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland | |
| 700 | 1 | |a Sromek, Maria |u Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland<email>filip.hajdyla@nio.gov.pl</email> (F.H.); <email>magdalena.chechlinska@nio.gov.pl</email> (M.Ch.) | |
| 700 | 1 | |a Błachnio, Katarzyna |u Flow Cytometry Laboratory, Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland | |
| 700 | 1 | |a Kulecka, Maria |u Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland; <email>lukszafron@gmail.com</email> (Ł.M.S.); | |
| 700 | 1 | |a Hajdyła, Filip |u Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland<email>filip.hajdyla@nio.gov.pl</email> (F.H.); <email>magdalena.chechlinska@nio.gov.pl</email> (M.Ch.) | |
| 700 | 1 | |a Goryca, Krzysztof |u Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland; <email>lukszafron@gmail.com</email> (Ł.M.S.); | |
| 700 | 1 | |a Chechlińska, Magdalena |u Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland<email>filip.hajdyla@nio.gov.pl</email> (F.H.); <email>magdalena.chechlinska@nio.gov.pl</email> (M.Ch.) | |
| 700 | 1 | |a Jan Konrad Siwicki |u Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland<email>filip.hajdyla@nio.gov.pl</email> (F.H.); <email>magdalena.chechlinska@nio.gov.pl</email> (M.Ch.) | |
| 773 | 0 | |t International Journal of Molecular Sciences |g vol. 26, no. 1 (2025), p. 285 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
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