Buchumschlag

Redundant, weakly connected prefrontal hemispheres balance precision and capacity in spatial working memory

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Veröffentlicht in:bioRxiv (Jan 16, 2025)
1. Verfasser: Tschiersch, Melanie
Weitere Verfasser: Umakantha, Akash, Williamson, Ryan C, Smith, Matthew A, Barbosa, Joao, Compte, Albert
Veröffentlicht:
Cold Spring Harbor Laboratory Press
Schlagworte:
Mental task performance
Memory
Visual field
Cerebral hemispheres
Spatial memory
Short term memory
Prefrontal cortex
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Abstract:How the prefrontal hemispheres coordinate to adapt to spatial working memory (WM) demands remains an open question. Recently, two models have been proposed: A specialized model, where each hemisphere governs contralateral behavior, and a redundant model, where both hemispheres equally guide behavior in the full visual space. To explore these alternatives, we analyzed simultaneous bilateral prefrontal cortex recordings from three macaque monkeys performing a visuo-spatial WM task. Each hemisphere represented targets across the full visual field and equally predicted behavioral imprecisions. Furthermore, memory errors were weakly correlated between hemispheres, suggesting that redundant, weakly coupled prefrontal hemispheres support spatial WM. Attractor model simulations showed that the hemispheric redundancy improved precision in simple tasks, whereas weak inter-hemispheric coupling allowed for specialized hemispheres in complex tasks. This interhemispheric architecture reconciles previous findings thought to support distinct models into a unified architecture, providing a versatile interhemispheric architecture that adapts to varying cognitive demands.Competing Interest StatementThe authors have declared no competing interest.
ISSN:2692-8205
DOI:10.1101/2025.01.15.633176
Quelle:Biological Science Database