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Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches

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Publicado en:International Journal of Molecular Sciences vol. 26, no. 3 (2025), p. 1204
Autor principal: Kim, Mi Eun
Otros Autores: Lee, Jun Sik
Publicado:
MDPI AG
Materias:
Physiology
Homeostasis
Pathogens
Diabetes
Disease
Rheumatoid arthritis
Sepsis
Hypertension
Cytokines
Leukocytes
Chronic illnesses
Cartilage
Reactive oxygen species
Blood platelets
Inflammation
Nitric oxide
Atherosclerosis
Kinases
Influence
Pathophysiology
Bioavailability
Oxidative stress
Proteins
Cancer
Enzymes
Pathogenesis
Molecules
Acceso en línea:Citation/Abstract
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Resumen:Nitric oxide synthases (NOS) are crucial enzymes responsible for the production of nitric oxide (NO), a signaling molecule with essential roles in vascular regulation, immune defense, and neurotransmission. The three NOS isoforms, endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS), are tightly regulated by inflammatory mediators and cellular signaling pathways. While physiological NO production is vital for maintaining homeostasis, dysregulated NOS activity contributes to the pathogenesis of numerous diseases, including cardiovascular disorders, neurodegenerative conditions, and cancer. Recent advances in understanding the molecular mechanisms of NOS regulation have unveiled novel therapeutic opportunities, including isoform-specific modulators, upstream pathways, and nanotechnology-enhanced delivery systems. This review highlights these advancements, offering insights into how targeting NOS and its regulatory network can enable precise and effective therapeutic strategies for managing inflammation-driven pathologies.
ISSN:1661-6596
1422-0067
DOI:10.3390/ijms26031204
Fuente:Health & Medical Collection