Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches

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書誌詳細
出版年:	International Journal of Molecular Sciences vol. 26, no. 3 (2025), p. 1204
第一著者:	Kim, Mi Eun
その他の著者:	Lee, Jun Sik
出版事項:	MDPI AG
主題:	Physiology Homeostasis Pathogens Diabetes Disease Rheumatoid arthritis Sepsis Hypertension Cytokines Leukocytes Chronic illnesses Cartilage Reactive oxygen species Blood platelets Inflammation Nitric oxide Atherosclerosis Kinases Influence Pathophysiology Bioavailability Oxidative stress Proteins Cancer Enzymes Pathogenesis Molecules
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その他の書誌記述
抄録:	Nitric oxide synthases (NOS) are crucial enzymes responsible for the production of nitric oxide (NO), a signaling molecule with essential roles in vascular regulation, immune defense, and neurotransmission. The three NOS isoforms, endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS), are tightly regulated by inflammatory mediators and cellular signaling pathways. While physiological NO production is vital for maintaining homeostasis, dysregulated NOS activity contributes to the pathogenesis of numerous diseases, including cardiovascular disorders, neurodegenerative conditions, and cancer. Recent advances in understanding the molecular mechanisms of NOS regulation have unveiled novel therapeutic opportunities, including isoform-specific modulators, upstream pathways, and nanotechnology-enhanced delivery systems. This review highlights these advancements, offering insights into how targeting NOS and its regulatory network can enable precise and effective therapeutic strategies for managing inflammation-driven pathologies.
ISSN:	1661-6596 1422-0067
DOI:	10.3390/ijms26031204
ソース:	Health & Medical Collection