Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting
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| Publicat a: | Frontiers in Cellular Neuroscience (Feb 12, 2025) |
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| Autor principal: | |
| Altres autors: | , , , , |
| Publicat: |
Frontiers Research Foundation
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| Matèries: | |
| Accés en línia: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 022 | |a 1662-5102 | ||
| 024 | 7 | |a 10.3389/fncel.2025.1542508 |2 doi | |
| 035 | |a 3165948050 | ||
| 045 | 0 | |b d20250212 | |
| 100 | 1 | |a Altshuler, Rachel D | |
| 245 | 1 | |a Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting | |
| 260 | |b Frontiers Research Foundation |c Feb 12, 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Introduction: In both rats and humans, methamphetamine (Meth) seeking progressively increases during abstinence, a behavioral phenomenon termed “incubation of Meth craving”. We previously demonstrated a critical role of dorsal striatum (DS) in this incubation in rats. However, circuit-specific molecular mechanisms in DS underlying this incubation are largely unknown. Here we combined a newly developed fluorescence-activated sorting (FACS) protocol with fluorescence-conjugated cholera toxin subunit B-647 (CTb-647, a retrograde tracer) to examine gene alterations in the direct-pathway (striatonigral) medium spiny neurons (MSNs) associated with incubation of Meth craving. | |
| 610 | 4 | |a University of Maryland | |
| 651 | 4 | |a United States--US | |
| 653 | |a Behavior | ||
| 653 | |a Cholera toxin | ||
| 653 | |a Catheters | ||
| 653 | |a Caudate-putamen | ||
| 653 | |a Molecular modelling | ||
| 653 | |a Spiny neurons | ||
| 653 | |a Flow cytometry | ||
| 653 | |a Genes | ||
| 653 | |a Neostriatum | ||
| 653 | |a Laboratory animals | ||
| 653 | |a Narcotics | ||
| 653 | |a Proteins | ||
| 653 | |a Fluorescence | ||
| 653 | |a Abstinence | ||
| 653 | |a Polyethylene | ||
| 653 | |a Dopamine | ||
| 653 | |a Surgery | ||
| 653 | |a FDA approval | ||
| 653 | |a Experiments | ||
| 653 | |a Methamphetamine | ||
| 653 | |a Cholera | ||
| 653 | |a Enzymes | ||
| 653 | |a Toxins | ||
| 653 | |a Roles | ||
| 653 | |a Neurosciences | ||
| 700 | 1 | |a Burke, Megan A M | |
| 700 | 1 | |a Garcia, Kristine T | |
| 700 | 1 | |a Class, Kenneth | |
| 700 | 1 | |a Cimbro, Raffaello | |
| 700 | 1 | |a Li, Xuan | |
| 773 | 0 | |t Frontiers in Cellular Neuroscience |g (Feb 12, 2025) | |
| 786 | 0 | |d ProQuest |t Science Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3165948050/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3165948050/fulltextwithgraphics/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3165948050/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |