Toxidromes and a general approach to poisoning

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Detalles Bibliográficos
Publicado en:	Archives of Disease in Childhood (Feb 2025), p. archdischild-2024-326969
Autor principal:	Hoffman, Robert J
Otros Autores:	Nillas, Andrea
Publicado:	BMJ Publishing Group LTD
Materias:	United Kingdom > UK Urinary retention Drug withdrawal Anticholinergics Delirium Toxicology Urination Pattern recognition Fatalities Poisoning Dopamine Blood pressure Enzymes Benzodiazepines Heart rate Convulsions & seizures Toxicity γ-Aminobutyric acid Vital signs Antidotes Poisons Patients Coma Cardiac arrhythmia Hypertension Psychosis Adrenergic receptors Opioid receptors Nervous system Toxins Pediatrics Literature Reviews Narcotics Anatomy Medical Evaluation Mnemonics Cocaine Physical Examinations Database Management Systems Visual Impairments Depression (Psychology) Social Meta Analysis
Acceso en línea:	Citation/Abstract Full Text Full Text - PDF
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Descripción
Resumen:	A toxicologic syndrome, or toxidrome, is a distinct pattern of effects of poisoning. Well-defined toxidromes are the opioid, anticholinergic, cholinergic and sympathomimetic, and an additional described toxidrome is GABAergic. These toxidromes are named for the receptor effects causing their specific clinical findings, and knowledge of toxidromes allows rapid pattern recognition of specific poisonings. In this review, toxidromes and the initial assessment and general approach to management of acute poisoning are discussed. This article details the receptor-level effects of the poisoning, key clinical signs and symptoms and the role antidotes play in treatment. Clinical resources such as Toxbase and others exist to provide detailed guidance on clinical management of poisoning.
ISSN:	0003-9888 1468-2044
DOI:	10.1136/archdischild-2024-326969
Fuente:	Science Database