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Congenital Heart Diseases: Recent Insights into Epigenetic Mechanisms

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Pubblicato in:Cells vol. 14, no. 11 (2025), p. 820
Autore principale: Rodríguez-Pérez, José Manuel
Altri autori: Ortega-Zhindón, Diego B, Villamil-Castañeda, Clara, Lara-Ortiz, Javier Santiago, Borgonio-Cuadra Verónica Marusa, Cervantes-Salazar, Jorge L, Calderón-Colmenero, Juan, Escalante-Ruiz Zeomara Nathali, Retama-Méndez Eduardo, Hernández-García, Yessica C, Pérez-Hernández Nonanzit
Pubblicazione:
MDPI AG
Soggetti:
DNA methylation
Womens health
Epigenetics
Arteries
Stem cells
Environmental factors
Heart diseases
Enzymes
Accesso online:Citation/Abstract
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Abstract:Congenital Heart Diseases (CHDs) are a heterogeneous group of structural abnormalities affecting the heart and major arteries, which are present in at least 1% of births worldwide. Studies have linked CHD to both genetic and environmental factors. In this regard, it has been demonstrated that changes in the epigenetic pattern impact the expression of key genes involved in proper cardiac development. Therefore, it is suggested that aberrant epigenetic mechanisms may contribute to the development of these pathologies. Here, we review and summarize the main epigenetic mechanisms involved in CHD. Moreover, cardiac development and the importance of the environment and CHD are also addressed.
ISSN:2073-4409
DOI:10.3390/cells14110820
Fonte:Biological Science Database