Congenital Heart Diseases: Recent Insights into Epigenetic Mechanisms

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Бібліографічні деталі
Опубліковано в::	Cells vol. 14, no. 11 (2025), p. 820
Автор:	Rodríguez-Pérez, José Manuel
Інші автори:	Ortega-Zhindón, Diego B, Villamil-Castañeda, Clara, Lara-Ortiz, Javier Santiago, Borgonio-Cuadra Verónica Marusa, Cervantes-Salazar, Jorge L, Calderón-Colmenero, Juan, Escalante-Ruiz Zeomara Nathali, Retama-Méndez Eduardo, Hernández-García, Yessica C, Pérez-Hernández Nonanzit
Опубліковано:	MDPI AG
Предмети:	DNA methylation Womens health Epigenetics Arteries Stem cells Environmental factors Heart diseases Enzymes
Онлайн доступ:	Citation/Abstract Full Text + Graphics Full Text - PDF
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Опис
Короткий огляд:	Congenital Heart Diseases (CHDs) are a heterogeneous group of structural abnormalities affecting the heart and major arteries, which are present in at least 1% of births worldwide. Studies have linked CHD to both genetic and environmental factors. In this regard, it has been demonstrated that changes in the epigenetic pattern impact the expression of key genes involved in proper cardiac development. Therefore, it is suggested that aberrant epigenetic mechanisms may contribute to the development of these pathologies. Here, we review and summarize the main epigenetic mechanisms involved in CHD. Moreover, cardiac development and the importance of the environment and CHD are also addressed.
ISSN:	2073-4409
DOI:	10.3390/cells14110820
Джерело:	Biological Science Database