Noncanonical short-latency auditory pathway directly activates deep cortical layers
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| Publicat a: | Nature Communications vol. 16, no. 1 (2025), p. 5911 |
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| Autor principal: | |
| Altres autors: | , , , , , , , |
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| Accés en línia: | Citation/Abstract Full Text Full Text - PDF |
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| 003 | UK-CbPIL | ||
| 022 | |a 2041-1723 | ||
| 024 | 7 | |a 10.1038/s41467-025-61020-9 |2 doi | |
| 035 | |a 3226280745 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 145839 |2 nlm | ||
| 100 | 1 | |a Garcia, Michellee M. |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 245 | 1 | |a Noncanonical short-latency auditory pathway directly activates deep cortical layers | |
| 260 | |b Nature Publishing Group |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs to layer 4 (L4) of the primary auditory cortex (A1). In this canonical model, A1 L4 inputs initiate a hierarchical cascade that propagates to higher-order cortices for slower integration of complex sounds. Here, we identify parallel ascending pathways in mice that bypass A1 and directly reach the secondary auditory cortex (A2), alongside the canonical hierarchical route. We found that layer 6 (L6) of both A1 and A2 receive short-latency (<10 ms) sound inputs via higher-order thalamic nuclei. Additionally, A2 L4 is innervated by a caudal subdivision of the traditionally defined primary thalamus, which we now re-classify as non-primary. Notably, both identified thalamic regions receive projections from distinct subdivisions of the higher-order inferior colliculus, which in turn receive direct projections from cochlear nucleus neurons. Thus, higher-order auditory cortex integrates both slower, pre-processed information and rapid, direct sensory inputs, enabling parallel processing of fast sensory information across cortical areas.In the canonical model of auditory processing, thalamocortical inputs to the primary auditory cortex initiate a hierarchical transmission to higher-order cortices. Here, authors reveal alternative auditory pathways that bypass the primary auditory cortex and directly activate higher-order cortex within <10 ms in mice, enabling parallel and distributed processing of fast sensory information across cortical areas. | |
| 653 | |a Inferior colliculus | ||
| 653 | |a Somatosensory cortex | ||
| 653 | |a Parallel processing | ||
| 653 | |a Bats | ||
| 653 | |a Thalamic nuclei | ||
| 653 | |a Cochlear nuclei | ||
| 653 | |a Hearing | ||
| 653 | |a Cerebral cortex | ||
| 653 | |a Cortex (auditory) | ||
| 653 | |a Information processing | ||
| 653 | |a Thalamus | ||
| 653 | |a Subdivisions | ||
| 653 | |a Latency | ||
| 653 | |a Auditory pathways | ||
| 653 | |a Sensory integration | ||
| 653 | |a Mann-Whitney U test | ||
| 653 | |a Cochlea | ||
| 653 | |a Distributed processing | ||
| 653 | |a Sound | ||
| 653 | |a Environmental | ||
| 700 | 1 | |a Kline, Amber M. |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Onodera, Koun |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Tsukano, Hiroaki |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Dandu, Pranathi R. |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Acosta, Hailey C. |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Kasten, Michael R. |u University of North Carolina at Chapel Hill, Department of Otolaryngology/Head and Neck Surgery, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Manis, Paul B. |u University of North Carolina at Chapel Hill, Department of Otolaryngology/Head and Neck Surgery, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Department of Cell Biology and Physiology, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208) | |
| 700 | 1 | |a Kato, Hiroyuki K. |u University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); University of North Carolina at Chapel Hill, Neuroscience Center, Chapel Hill, USA (GRID:grid.10698.36) (ISNI:0000 0001 2248 3208); Massachusetts Eye and Ear, Eaton-Peabody Laboratories, Boston, USA (GRID:grid.39479.30) (ISNI:0000 0000 8800 3003); Harvard Medical School, Department of Otolaryngology - Head and Neck Surgery, Boston, USA (GRID:grid.38142.3c) (ISNI:000000041936754X) | |
| 773 | 0 | |t Nature Communications |g vol. 16, no. 1 (2025), p. 5911 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3226280745/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3226280745/fulltext/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3226280745/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |