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Noncanonical short-latency auditory pathway directly activates deep cortical layers

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Publicado en:Nature Communications vol. 16, no. 1 (2025), p. 5911
Autor principal: Garcia, Michellee M.
Otros Autores: Kline, Amber M., Onodera, Koun, Tsukano, Hiroaki, Dandu, Pranathi R., Acosta, Hailey C., Kasten, Michael R., Manis, Paul B., Kato, Hiroyuki K.
Publicado:
Nature Publishing Group
Materias:
Inferior colliculus
Somatosensory cortex
Parallel processing
Bats
Thalamic nuclei
Cochlear nuclei
Hearing
Cerebral cortex
Cortex (auditory)
Information processing
Thalamus
Subdivisions
Latency
Auditory pathways
Sensory integration
Mann-Whitney U test
Cochlea
Distributed processing
Sound
Environmental
Acceso en línea:Citation/Abstract
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Resumen:Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs to layer 4 (L4) of the primary auditory cortex (A1). In this canonical model, A1 L4 inputs initiate a hierarchical cascade that propagates to higher-order cortices for slower integration of complex sounds. Here, we identify parallel ascending pathways in mice that bypass A1 and directly reach the secondary auditory cortex (A2), alongside the canonical hierarchical route. We found that layer 6 (L6) of both A1 and A2 receive short-latency (<10 ms) sound inputs via higher-order thalamic nuclei. Additionally, A2 L4 is innervated by a caudal subdivision of the traditionally defined primary thalamus, which we now re-classify as non-primary. Notably, both identified thalamic regions receive projections from distinct subdivisions of the higher-order inferior colliculus, which in turn receive direct projections from cochlear nucleus neurons. Thus, higher-order auditory cortex integrates both slower, pre-processed information and rapid, direct sensory inputs, enabling parallel processing of fast sensory information across cortical areas.In the canonical model of auditory processing, thalamocortical inputs to the primary auditory cortex initiate a hierarchical transmission to higher-order cortices. Here, authors reveal alternative auditory pathways that bypass the primary auditory cortex and directly activate higher-order cortex within <10 ms in mice, enabling parallel and distributed processing of fast sensory information across cortical areas.
ISSN:2041-1723
DOI:10.1038/s41467-025-61020-9
Fuente:Health & Medical Collection