Buchumschlag

Comparative efficacy of pharmacological and non-pharmacological interventions on pain intensity of primary dysmenorrhoea: protocol for systematic review and network meta-analysis

Gespeichert in:
Veröffentlicht in:BMJ Open vol. 15, no. 7 (2025), p. e089282
1. Verfasser: Bao, QiongNan
Weitere Verfasser: Yao, Jin, Du, XiaoLi, Li, YaQin, Zhang, XinYue, ManZe Xia, Chen, ZhengHong, Zhong, WanQi, Wu, KeXin, Yin, ZiHan, Liang, FanRong
Veröffentlicht:
BMJ Publishing Group LTD
Schlagworte:
Mental depression
Manipulative therapy
Dietary supplements
Transcutaneous electrical nerve stimulation-TENS
Quality of life
Socioeconomic factors
Anxiety
Intervention
Clinical trials
Pain
Pharmacology
Comparative analysis
Non-pharmacological intervention
Online-Zugang:Citation/Abstract
Full Text + Graphics
Full Text - PDF
Tags: Tag hinzufügen
Keine Tags, Fügen Sie das erste Tag hinzu!
Abstract:IntroductionPrimary dysmenorrhoea (PD) is the most common gynaecological condition among young women and is associated with significant socioeconomic repercussions. It is unclear which works best for pain relief when pharmacological and non-pharmacological interventions are compared. This systematic review and network meta-analysis (NMA) will aim to compare and rank the effects of pharmacological and non-pharmacological interventions in patients with PD.Methods and analysisRandomised controlled trials of pharmacological and non-pharmacological interventions for PD will be identified via a search of the PubMed, Cochrane Library, Web of Science, Embase, Scopus database and Google Scholar search engine until September 2025. The primary outcome will be a change in pain intensity among patients with PD, while the secondary outcomes include health-related quality of life, symptoms of depression and anxiety, and treatment-related adverse events. Two independent reviewers will perform document screening, study selection and data extraction. The methodological quality of the included studies will be assessed using the Cochrane Risk of Bias tool (V.2). The RevMan, Stata and Aggregate Data Drug Information System software will be used to perform a pairwise meta-analysis and Bayesian NMA in a random-effects model. The certainty of the evidence will be rated using the Grading of Recommendations, Assessment, Development, and Evaluation System.Ethics and disseminationThis systematic review protocol is exempt from ethical approval as it involves analysis of previously published data. The findings of this review will be submitted to peer-reviewed journals.Trial Registration numberCRD42024543573.
ISSN:2044-6055
DOI:10.1136/bmjopen-2024-089282
Quelle:Consumer Health Database