Comparative efficacy of pharmacological and non-pharmacological interventions on pain intensity of primary dysmenorrhoea: protocol for systematic review and network meta-analysis
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| Publicado en: | BMJ Open vol. 15, no. 7 (2025), p. e089282 |
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| Autor principal: | |
| Otros Autores: | , , , , , , , , , |
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BMJ Publishing Group LTD
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| Acceso en línea: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 003 | UK-CbPIL | ||
| 022 | |a 2044-6055 | ||
| 024 | 7 | |a 10.1136/bmjopen-2024-089282 |2 doi | |
| 035 | |a 3227479845 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 269834 |2 nlm | ||
| 100 | 1 | |a Bao, QiongNan |u Department of Traditional Chinese Medicine, First People’s Hospital of Yunnan, Kunming, Yunnan, China; School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 245 | 1 | |a Comparative efficacy of pharmacological and non-pharmacological interventions on pain intensity of primary dysmenorrhoea: protocol for systematic review and network meta-analysis | |
| 260 | |b BMJ Publishing Group LTD |c 2025 | ||
| 513 | |a Evidence Based Healthcare Journal Article | ||
| 520 | 3 | |a IntroductionPrimary dysmenorrhoea (PD) is the most common gynaecological condition among young women and is associated with significant socioeconomic repercussions. It is unclear which works best for pain relief when pharmacological and non-pharmacological interventions are compared. This systematic review and network meta-analysis (NMA) will aim to compare and rank the effects of pharmacological and non-pharmacological interventions in patients with PD.Methods and analysisRandomised controlled trials of pharmacological and non-pharmacological interventions for PD will be identified via a search of the PubMed, Cochrane Library, Web of Science, Embase, Scopus database and Google Scholar search engine until September 2025. The primary outcome will be a change in pain intensity among patients with PD, while the secondary outcomes include health-related quality of life, symptoms of depression and anxiety, and treatment-related adverse events. Two independent reviewers will perform document screening, study selection and data extraction. The methodological quality of the included studies will be assessed using the Cochrane Risk of Bias tool (V.2). The RevMan, Stata and Aggregate Data Drug Information System software will be used to perform a pairwise meta-analysis and Bayesian NMA in a random-effects model. The certainty of the evidence will be rated using the Grading of Recommendations, Assessment, Development, and Evaluation System.Ethics and disseminationThis systematic review protocol is exempt from ethical approval as it involves analysis of previously published data. The findings of this review will be submitted to peer-reviewed journals.Trial Registration numberCRD42024543573. | |
| 653 | |a Mental depression | ||
| 653 | |a Manipulative therapy | ||
| 653 | |a Dietary supplements | ||
| 653 | |a Transcutaneous electrical nerve stimulation-TENS | ||
| 653 | |a Quality of life | ||
| 653 | |a Socioeconomic factors | ||
| 653 | |a Anxiety | ||
| 653 | |a Intervention | ||
| 653 | |a Clinical trials | ||
| 653 | |a Pain | ||
| 653 | |a Pharmacology | ||
| 653 | |a Comparative analysis | ||
| 653 | |a Non-pharmacological intervention | ||
| 700 | 1 | |a Yao, Jin |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Du, XiaoLi |u Sichuan Nanchong Mental Health Center, Nanchong, China | |
| 700 | 1 | |a Li, YaQin |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Zhang, XinYue |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a ManZe Xia |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Chen, ZhengHong |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Zhong, WanQi |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Wu, KeXin |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Yin, ZiHan |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 700 | 1 | |a Liang, FanRong |u Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China | |
| 773 | 0 | |t BMJ Open |g vol. 15, no. 7 (2025), p. e089282 | |
| 786 | 0 | |d ProQuest |t Consumer Health Database | |
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| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3227479845/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
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