Drug Discovery and Development
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| Publicat a: | Asian Journal of Research in Pharmaceutical Science vol. 15, no. 2 (Jun 2025) |
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| Accés en línia: | Citation/Abstract Full Text |
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| Resum: | [...]prudent investments and measured risks at this eventually, a specific moment can raise the risk of success for a new Potential4,6. The different stages or phases of the drug development and discovery process are20-24 Drug Discovery Period25-31 * Initiate drug discovery program Combinatorial chemistry * Lead compound series identification * Additional compounds are made NCE’ s identified Drug Development and Registration Period32-35 * IND plan established and initiated * IND filed * Clinical studies initiated * NDA prepared and submitted * Drug launched into the market Drug Marketing and Line Expansion36-41 * Post-Marketing surveillance initiated * New clinical indications pursued * New dosage forms and formulations developed * Activities conducted to support marketing Drug Discovery and Development: Drug Discovery: New studies into a disease process that motivate scientists to create a new product to prevent or reverse the disease’s effects are the usual ways that researchers find new drugs42,44. * Numerous molecular compound tests to identify potential protective effects against a wide range of illnesses * Current therapies with unexpected side effects45–51 * New technologies, such as those that offer novel approaches to genetic material manipulation or the delivery of pharmaceuticals to particular bodily locations52–54. Drug Development: After discovering a compound that shows promise for development, scientists carry out tests in order to understand more about60–66: * Its distribution, metabolism, excretion, and absorption * Its possible advantages and modes of action * The ideal dosage and method of delivery * Adverse effects also known as toxicity * The ways in which it impacts different age groups (e.g., by gender, race, or ethnicity) differently * How it affects other medications and therapies * Its efficacy in comparison to comparable medications Preclinical Trials: ICH has established a basic guideline for the technical necessities of acceptable preclinical drug development. Prior to the start of a clinical trial, researchers review existing data about the drug to formulate research questions and objectives75. * Selection criteria for participants * Number of people take part of the study * Duration of study * Dose and route of administration of dosage form * Assessment of parameters * Data collection and analysis Phase 1: |
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| ISSN: | 2231-5640 2231-5659 |
| Font: | Health & Medical Collection |