Targeted Degradation Technologies Utilizing Autophagy
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| Publicado en: | International Journal of Molecular Sciences vol. 26, no. 14 (2025), p. 6576-6601 |
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| Autor principal: | |
| Otros Autores: | , , , , , , , , , |
| Publicado: |
MDPI AG
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| Acceso en línea: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 022 | |a 1661-6596 | ||
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| 024 | 7 | |a 10.3390/ijms26146576 |2 doi | |
| 035 | |a 3233223422 | ||
| 045 | 2 | |b d20250715 |b d20250731 | |
| 084 | |a 231645 |2 nlm | ||
| 100 | 1 | |a Zhou Zeyu |u Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518000, China; zy.zhou1@siat.ac.cn (Z.Z.); wj.zhou@siat.ac.cn (W.Z.); h.tian@siat.ac.cn (H.T.) | |
| 245 | 1 | |a Targeted Degradation Technologies Utilizing Autophagy | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Review | ||
| 520 | 3 | |a Targeted degradation technologies, primarily referring to targeted protein degradation, have emerged as promising drug discovery strategies. In contrast to traditional “occupancy-driven” inhibition approaches, these technologies ingeniously leverage the cell’s endogenous degradation mechanisms to achieve specific elimination of disease-causing targets. Autophagy, a highly conserved cellular clearance pathway, possesses broad substrate recognition capabilities, enabling degradation of not only individual proteins but also protein aggregates, damaged organelles, and invading pathogens. Given these characteristics, researchers are actively exploring the application of autophagy mechanisms in targeted degradation technologies. Herein, we summarize recent advances in autophagy-dependent degradation approaches, including autophagosome tethering compounds (ATTEC), autophagy-targeting chimeras (AUTAC), autophagy-targeting Chimera (AUTOTAC), chaperone-mediated autophagy (CMA)-based methods, nanotechnology-based strategies, and the newly introduced autophagy-induced antibody (AUTAB) technique, highlighting their mechanisms, advantages, and potential applications in treating tumors, neurodegenerative diseases, and other challenging conditions. | |
| 653 | |a Amino acids | ||
| 653 | |a Autophagy | ||
| 653 | |a Enzymes | ||
| 653 | |a Kinases | ||
| 653 | |a Proteins | ||
| 700 | 1 | |a Liang Jiaming |u Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; jm.liang@siat.ac.cn (J.L.); bh.cheng@siat.ac.cn (B.C.); yy.li@siat.ac.cn (Y.L.); wl.shi@siat.ac.cn (W.S.) | |
| 700 | 1 | |a Cheng Binghua |u Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; jm.liang@siat.ac.cn (J.L.); bh.cheng@siat.ac.cn (B.C.); yy.li@siat.ac.cn (Y.L.); wl.shi@siat.ac.cn (W.S.) | |
| 700 | 1 | |a Li, Yanyan |u Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; jm.liang@siat.ac.cn (J.L.); bh.cheng@siat.ac.cn (B.C.); yy.li@siat.ac.cn (Y.L.); wl.shi@siat.ac.cn (W.S.) | |
| 700 | 1 | |a Zhou, Wenjie |u Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518000, China; zy.zhou1@siat.ac.cn (Z.Z.); wj.zhou@siat.ac.cn (W.Z.); h.tian@siat.ac.cn (H.T.) | |
| 700 | 1 | |a Tian, Hui |u Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518000, China; zy.zhou1@siat.ac.cn (Z.Z.); wj.zhou@siat.ac.cn (W.Z.); h.tian@siat.ac.cn (H.T.) | |
| 700 | 1 | |a Shi, Wenli |u Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; jm.liang@siat.ac.cn (J.L.); bh.cheng@siat.ac.cn (B.C.); yy.li@siat.ac.cn (Y.L.); wl.shi@siat.ac.cn (W.S.) | |
| 700 | 1 | |a Liu, Ke |u Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518028, China; ke.liu@siat.ac.cn (K.L.); lj.fang@siat.ac.cn (L.F.) | |
| 700 | 1 | |a Fang Lijing |u Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518028, China; ke.liu@siat.ac.cn (K.L.); lj.fang@siat.ac.cn (L.F.) | |
| 700 | 1 | |a Li Hongchang |u Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518028, China; ke.liu@siat.ac.cn (K.L.); lj.fang@siat.ac.cn (L.F.) | |
| 700 | 1 | |a Shao Ximing |u Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; jm.liang@siat.ac.cn (J.L.); bh.cheng@siat.ac.cn (B.C.); yy.li@siat.ac.cn (Y.L.); wl.shi@siat.ac.cn (W.S.) | |
| 773 | 0 | |t International Journal of Molecular Sciences |g vol. 26, no. 14 (2025), p. 6576-6601 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3233223422/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3233223422/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3233223422/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |