Targeted Degradation Technologies Utilizing Autophagy

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Podrobná bibliografie
Vydáno v:	International Journal of Molecular Sciences vol. 26, no. 14 (2025), p. 6576-6601
Hlavní autor:	Zhou Zeyu
Další autoři:	Liang Jiaming, Cheng Binghua, Li, Yanyan, Zhou, Wenjie, Tian, Hui, Shi, Wenli, Liu, Ke, Fang Lijing, Li Hongchang, Shao Ximing
Vydáno:	MDPI AG
Témata:	Amino acids Autophagy Enzymes Kinases Proteins
On-line přístup:	Citation/Abstract Full Text + Graphics Full Text - PDF
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Popis
Abstrakt:	Targeted degradation technologies, primarily referring to targeted protein degradation, have emerged as promising drug discovery strategies. In contrast to traditional “occupancy-driven” inhibition approaches, these technologies ingeniously leverage the cell’s endogenous degradation mechanisms to achieve specific elimination of disease-causing targets. Autophagy, a highly conserved cellular clearance pathway, possesses broad substrate recognition capabilities, enabling degradation of not only individual proteins but also protein aggregates, damaged organelles, and invading pathogens. Given these characteristics, researchers are actively exploring the application of autophagy mechanisms in targeted degradation technologies. Herein, we summarize recent advances in autophagy-dependent degradation approaches, including autophagosome tethering compounds (ATTEC), autophagy-targeting chimeras (AUTAC), autophagy-targeting Chimera (AUTOTAC), chaperone-mediated autophagy (CMA)-based methods, nanotechnology-based strategies, and the newly introduced autophagy-induced antibody (AUTAB) technique, highlighting their mechanisms, advantages, and potential applications in treating tumors, neurodegenerative diseases, and other challenging conditions.
ISSN:	1661-6596 1422-0067
DOI:	10.3390/ijms26146576
Zdroj:	Health & Medical Collection