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Biochemical neuroplasticity in the cerebellum after physical exercise: Systematic review and meta-analysis

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Publicado en:PLoS One vol. 20, no. 8 (Aug 2025), p. e0309259
Autor principal: Marcio Gonçalves Corrêa
Otros Autores: Thais Alves Lobão, Gabriel Mesquita da Conceição Bahia, Erica Miranda Sanches Aires, Rebeca da Costa Gomes, Jeffeson Hildo Medeiros de Queiroz, Marta Chagas Monteiro, Carlomagno Pacheco Bahia
Publicado:
Public Library of Science
Materias:
Software
Exercise
Bias
Cerebellum
Enzymatic activity
Environmental changes
Peroxidase
Physical exercise
Central nervous system
Lipid peroxidation
In vivo methods and tests
Neuroplasticity
Superoxide dismutase
Oxidative stress
Qualitative analysis
Catalase
Glutathione
Peroxidation
Nervous tissues
Biochemistry
Quantitative analysis
Cerebellar plasticity
Lipids
Meta-analysis
Glutathione peroxidase
Enzymes
Population studies
Systematic review
Social
Acceso en línea:Citation/Abstract
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Resumen:BackgroundNeuroplasticity is the central nervous system’s (CNS) capacity to adapt to injuries or environmental changes. Biochemical neuroplasticity is one such adaptation that may occur in response to physical exercise (PE). This systematic review and meta-analysis aimed to evaluate the effects of PE on cerebellar biochemical neuroplasticity.MethodsFollowing the PICO strategy, this review included in vivo studies with small rodents (Population) subjected to well-defined PE protocols (Intervention) and compared to non-exercised controls (Comparator) to assess cerebellar biochemical alterations (Outcome). Studies published between January 1976 and July 2024 without language restrictions were searched in PubMed, Scopus, Web of Science, and Cochrane Central databases. Data were synthesized through meta-analyses and methodological quality was assessed by the SYRCLE risk of bias tool.ResultsOut of 3,107 records screened, six studies met the inclusion criteria for qualitative and quantitative analyses. All studies had a low or unclear risk of bias. Markers of biochemical neuroplasticity assessed included superoxide dismutase (SOD), catalase (CAT), glutathione (GR), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione disulphide (GSSG) and lipid peroxidation (LPO). Meta-analyses showed that moderate-volume PE significantly reduced LPO (SMD = −2.41; 95% CI: −3.89 to −0.93), while high-volume PE increased LPO (SMD = 4.55; 95% CI: 1.92 to 7.18). Low-intensity or low-volume PE did not significantly alter oxidative markers.ConclusionsPE induces either adaptive or maladaptive biochemical neuroplasticity in the cerebellum depending on protocol variables. While enzymatic activity responds to cellular changes and limits nervous tissue protection, adaptive biochemical neuroplasticity seems to confer greater resistance and efficiency.
ISSN:1932-6203
DOI:10.1371/journal.pone.0309259
Fuente:Health & Medical Collection