Biochemical neuroplasticity in the cerebellum after physical exercise: Systematic review and meta-analysis
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| Publicado en: | PLoS One vol. 20, no. 8 (Aug 2025), p. e0309259 |
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| Otros Autores: | , , , , , , |
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Public Library of Science
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| Acceso en línea: | Citation/Abstract Full Text Full Text - PDF |
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| 001 | 3235680836 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1932-6203 | ||
| 024 | 7 | |a 10.1371/journal.pone.0309259 |2 doi | |
| 035 | |a 3235680836 | ||
| 045 | 2 | |b d20250801 |b d20250831 | |
| 084 | |a 174835 |2 nlm | ||
| 100 | 1 | |a Marcio Gonçalves Corrêa | |
| 245 | 1 | |a Biochemical neuroplasticity in the cerebellum after physical exercise: Systematic review and meta-analysis | |
| 260 | |b Public Library of Science |c Aug 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a BackgroundNeuroplasticity is the central nervous system’s (CNS) capacity to adapt to injuries or environmental changes. Biochemical neuroplasticity is one such adaptation that may occur in response to physical exercise (PE). This systematic review and meta-analysis aimed to evaluate the effects of PE on cerebellar biochemical neuroplasticity.MethodsFollowing the PICO strategy, this review included in vivo studies with small rodents (Population) subjected to well-defined PE protocols (Intervention) and compared to non-exercised controls (Comparator) to assess cerebellar biochemical alterations (Outcome). Studies published between January 1976 and July 2024 without language restrictions were searched in PubMed, Scopus, Web of Science, and Cochrane Central databases. Data were synthesized through meta-analyses and methodological quality was assessed by the SYRCLE risk of bias tool.ResultsOut of 3,107 records screened, six studies met the inclusion criteria for qualitative and quantitative analyses. All studies had a low or unclear risk of bias. Markers of biochemical neuroplasticity assessed included superoxide dismutase (SOD), catalase (CAT), glutathione (GR), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione disulphide (GSSG) and lipid peroxidation (LPO). Meta-analyses showed that moderate-volume PE significantly reduced LPO (SMD = −2.41; 95% CI: −3.89 to −0.93), while high-volume PE increased LPO (SMD = 4.55; 95% CI: 1.92 to 7.18). Low-intensity or low-volume PE did not significantly alter oxidative markers.ConclusionsPE induces either adaptive or maladaptive biochemical neuroplasticity in the cerebellum depending on protocol variables. While enzymatic activity responds to cellular changes and limits nervous tissue protection, adaptive biochemical neuroplasticity seems to confer greater resistance and efficiency. | |
| 653 | |a Software | ||
| 653 | |a Exercise | ||
| 653 | |a Bias | ||
| 653 | |a Cerebellum | ||
| 653 | |a Enzymatic activity | ||
| 653 | |a Environmental changes | ||
| 653 | |a Peroxidase | ||
| 653 | |a Physical exercise | ||
| 653 | |a Central nervous system | ||
| 653 | |a Lipid peroxidation | ||
| 653 | |a In vivo methods and tests | ||
| 653 | |a Neuroplasticity | ||
| 653 | |a Superoxide dismutase | ||
| 653 | |a Oxidative stress | ||
| 653 | |a Qualitative analysis | ||
| 653 | |a Catalase | ||
| 653 | |a Glutathione | ||
| 653 | |a Peroxidation | ||
| 653 | |a Nervous tissues | ||
| 653 | |a Biochemistry | ||
| 653 | |a Quantitative analysis | ||
| 653 | |a Cerebellar plasticity | ||
| 653 | |a Lipids | ||
| 653 | |a Meta-analysis | ||
| 653 | |a Glutathione peroxidase | ||
| 653 | |a Enzymes | ||
| 653 | |a Population studies | ||
| 653 | |a Systematic review | ||
| 653 | |a Social | ||
| 700 | 1 | |a Thais Alves Lobão | |
| 700 | 1 | |a Gabriel Mesquita da Conceição Bahia | |
| 700 | 1 | |a Erica Miranda Sanches Aires | |
| 700 | 1 | |a Rebeca da Costa Gomes | |
| 700 | 1 | |a Jeffeson Hildo Medeiros de Queiroz | |
| 700 | 1 | |a Marta Chagas Monteiro | |
| 700 | 1 | |a Carlomagno Pacheco Bahia | |
| 773 | 0 | |t PLoS One |g vol. 20, no. 8 (Aug 2025), p. e0309259 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3235680836/abstract/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text |u https://www.proquest.com/docview/3235680836/fulltext/embedded/75I98GEZK8WCJMPQ?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3235680836/fulltextPDF/embedded/75I98GEZK8WCJMPQ?source=fedsrch |