Distinct neural representational changes following cross-format number tutoring in children with mathematical difficulties

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Pubblicato in:NPJ Science of Learning vol. 10, no. 1 (2025), p. 52-66
Autore principale: Park, Yunji
Altri autori: Zhang, Yuan, Schwartz, Flora, Iuculano, Teresa, Chang, Hyesang, Menon, Vinod
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Nature Publishing Group
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024 7 |a 10.1038/s41539-025-00345-y  |2 doi 
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045 2 |b d20250101  |b d20251231 
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100 1 |a Park, Yunji  |u Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956) 
245 1 |a Distinct neural representational changes following cross-format number tutoring in children with mathematical difficulties 
260 |b Nature Publishing Group  |c 2025 
513 |a Journal Article 
520 3 |a Children with mathematical difficulties (MD) often struggle to connect abstract numerical symbols with corresponding nonsymbolic quantities, a foundational skill for mathematical development. We evaluated a 4-week personalized cross-format number (CFN) tutoring program designed to strengthen these symbolic–nonsymbolic mappings in children with MD aged 7–10 years. CFN tutoring was associated with significant improvements in numerical and arithmetic fluency. Neural representational similarity (NRS) analysis revealed that deficient cross-format NRS in children with MD was normalized following tutoring, aligning with pre-tutoring levels of typically-developing (TD) peers. This normalization was most pronounced in parietal and parahippocampal regions known to support quantity and spatial representation. We observed a distinctive pattern of neural plasticity across groups—children with MD showed increased cross-format NRS following tutoring, while TD children showed a decrease—suggesting a nonlinear, skill-dependent plasticity. These findings underscore the need for developmentally tailored interventions to support children with MD through targeted, evidence-based strategies. 
653 |a Mathematics 
653 |a Neuroimaging 
653 |a Brain research 
653 |a Medical imaging 
653 |a Skills 
653 |a Tutoring 
653 |a Children 
653 |a Number systems 
653 |a Hypotheses 
653 |a Neuroplasticity 
653 |a Skill development 
653 |a Multivariate Analysis 
653 |a Number Concepts 
653 |a Mathematics Skills 
653 |a Learning Problems 
653 |a Mathematics Education 
653 |a Mathematical Aptitude 
653 |a Brain 
653 |a Arithmetic 
653 |a Response to Intervention 
653 |a Transfer of Training 
653 |a Child Development 
653 |a Tutorial Programs 
653 |a Problem Solving 
653 |a Childhood Needs 
653 |a Cognitive Ability 
653 |a Schematic Studies 
700 1 |a Zhang, Yuan  |u Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956) 
700 1 |a Schwartz, Flora  |u CLLE, Université de Toulouse & CNRS, Toulouse, France (ROR: https://ror.org/004raaa70) (GRID: grid.508721.9) (ISNI: 0000 0001 2353 1689) 
700 1 |a Iuculano, Teresa  |u Centre National de la Recherche Scientifique & Université Paris Sorbonne, Paris, France (ROR: https://ror.org/02feahw73) (GRID: grid.4444.0) (ISNI: 0000 0001 2112 9282) 
700 1 |a Chang, Hyesang  |u Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956) 
700 1 |a Menon, Vinod  |u Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956); Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956); Stanford Neuroscience Institute, Stanford University, Stanford, California, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956); Symbolic Systems Program, Stanford University, Stanford, California, CA, USA (ROR: https://ror.org/00f54p054) (GRID: grid.168010.e) (ISNI: 0000 0004 1936 8956) 
773 0 |t NPJ Science of Learning  |g vol. 10, no. 1 (2025), p. 52-66 
786 0 |d ProQuest  |t Health & Medical Collection 
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