Obálka

High-Speed 1024-Pixel CMOS Electrochemical Imaging Sensor with 40,000 Frames per Second for Dopamine and Hydrogen Peroxide Imaging

Uloženo v:
Vydáno v:Electronics vol. 14, no. 16 (2025), p. 3207-3222
Hlavní autor: White, Kevin A
Další autoři: Crocker, Matthew A, Kim, Brian N
Vydáno:
MDPI AG
Témata:
Universal Serial Bus
Data acquisition
Electrodes
Semiconductors
Hydrogen peroxide
Disease
Frames per second
Signal processing
Brain
CMOS
Field programmable gate arrays
Data acquisition systems
Oxidative stress
Chemical sensors
Frames (data processing)
Dopamine
Man-machine interfaces
Sensors
Electrophysiology
Sensor arrays
Design
Digitization
Arrays
Portable computers
Data transmission
Parkinson's disease
Interfaces
On-line přístup:Citation/Abstract
Full Text + Graphics
Full Text - PDF
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstrakt:Electrochemical sensing arrays enable the spatial study of dopamine levels throughout brain slices, the diffusion of electroactive molecules, as well as neurotransmitter secretion from single cells. The integration of complementary metal-oxide semiconductor (CMOS) devices in the development of electrochemical sensing devices enables large-scale parallel recordings, providing beneficial high-throughput for drug screening studies, brain–machine interfaces, and single-cell electrophysiology. In this paper, an electrochemical sensor capable of recording at 40,000 frames per second using a CMOS sensor array with 1024 electrochemical detectors and a custom field-programmable gate array data acquisition system is detailed. A total of 1024 on-chip electrodes are monolithically integrated onto the designed CMOS chip through post-CMOS fabrication. Each electrode is paired with a dedicated transimpedance amplifier, providing 1024 parallel electrochemical sensors for high-throughput studies. To support the level of data generated by the electrochemical device, a powerful data acquisition system is designed to operate the sensor array as well as digitize and transmit the output of the CMOS chip. Using the presented electrochemical sensing system, both dopamine and hydrogen peroxide diffusions across the sensor array are successfully recorded at 40,000 frames per second across the 32 × 32 electrochemical detector array.
ISSN:2079-9292
DOI:10.3390/electronics14163207
Zdroj:Advanced Technologies & Aerospace Database