A Time-Continuous Model for an Untreated HIV-Infection and a Novel Non-Standard Finite-Difference-Method for Its Discretization
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| Pubblicato in: | Computer Modeling in Engineering & Sciences vol. 144, no. 2 (2025), p. 2191-2230 |
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Tech Science Press
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| Accesso online: | Citation/Abstract Full Text - PDF |
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| Abstract: | In this work, we re-investigate a classical mathematical model of untreated HIV infection suggested by Kirschner and introduce a novel non-standard finite-difference method for its numerical solution. As our first contribution, we establish non-negativity, boundedness of some solution components, existence globally in time, and uniqueness on a time interval for an arbitrary for the time-continuous problem which extends known results of Kirschner’s model in the literature. As our second analytical result, we establish different equilibrium states and examine their stability properties in the time-continuous setting or discuss some numerical tools to evaluate this question. Our third contribution is the formulation of a non-standard finite-difference method which preserves non-negativity, boundedness of some time-discrete solution components, equilibria, and their stabilities. As our final theoretical result, we prove linear convergence of our non-standard finite-difference-formulation towards the time-continuous solution. Conclusively, we present numerical examples to illustrate our theoretical findings. |
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| ISSN: | 1526-1492 1526-1506 |
| DOI: | 10.32604/cmes.2025.067397 |
| Fonte: | Advanced Technologies & Aerospace Database |