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Genetic Characterization of Staphylococcus aureus Isolates Associated with Toxic Shock Syndrome Toxin Production: An Epidemiological and Bioinformatics Approach

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Publicado en:Toxins vol. 17, no. 9 (2025), p. 440-453
Autor principal: Aguirre-Sánchez, J R
Otros Autores: Chaidez-Quiroz, C, Castro-del Campo Nohemi, Castro-del, Campo Nohelia
Publicado:
MDPI AG
Materias:
Mexico
Environmental information
Virulence factors
Epidemiology
Nosocomial infection
Bioinformatics
Cytokines
Dairy industry
Staphylococcus infections
Septic shock
Genomes
Genomics
Virulence
Foodborne diseases
Opportunist infection
Proteins
Public health
Cattle
Information processing
Food safety
Enterotoxins
Toxins
Pathogens
Data processing
Phylogenetics
Food contamination & poisoning
Biofilms
Phosphotransferase
Toxic shock syndrome
Gram-positive bacteria
Genes
Staphylococcal enterotoxin F
Mastitis
ABC transporters
Nosocomial infections
Epidemics
Economic
Staphylococcus aureus
Acceso en línea:Citation/Abstract
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Resumen:Staphylococcus aureus is an opportunistic pathogen, a member of the ESKAPE group, associated with nosocomial infections and foodborne illnesses due to its production of various toxins. This study conducted a comprehensive genomic characterization of S. aureus isolates producing toxic shock syndrome toxin (TSST-1) using a comparative genomics and bioinformatics approach. A total of 166, including 3 bovine mastitis isolates and 163 public genomes, were analyzed. Twenty-eight distinct sequence types (STs) were identified, with ST30 and ST5 being the most prevalent, corresponding to the clonal complexes CC30 and CC5, respectively. Phylogenetic reconstruction revealed two major clades aligned with these complexes, each exhibiting unique virulence factor profiles. Notably, TSST-1 was detected in bovine mastitis genomes, alongside a broad repertoire of virulence markers, such as enterotoxins and secretion system components, posing a potential risk to public health. Additionally, genes related to environmental information processing systems, including ABC transporters and phosphotransferase systems, were prevalent. These results underscore the need for strengthened genomic surveillance and the implementation of both preventive and corrective measures in dairy herds to mitigate zoonotic transmission and ensure food safety.
ISSN:2072-6651
DOI:10.3390/toxins17090440
Fuente:Health & Medical Collection