Genetic Characterization of Staphylococcus aureus Isolates Associated with Toxic Shock Syndrome Toxin Production: An Epidemiological and Bioinformatics Approach
محفوظ في:
| الحاوية / القاعدة: | Toxins vol. 17, no. 9 (2025), p. 440-453 |
|---|---|
| المؤلف الرئيسي: | |
| مؤلفون آخرون: | , , |
| منشور في: |
MDPI AG
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | Citation/Abstract Full Text + Graphics Full Text - PDF |
| الوسوم: |
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
MARC
| LEADER | 00000nab a2200000uu 4500 | ||
|---|---|---|---|
| 001 | 3254652528 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 2072-6651 | ||
| 024 | 7 | |a 10.3390/toxins17090440 |2 doi | |
| 035 | |a 3254652528 | ||
| 045 | 2 | |b d20250101 |b d20251231 | |
| 084 | |a 231638 |2 nlm | ||
| 100 | 1 | |a Aguirre-Sánchez, J R |u Laboratorio Nacional para la Investigación en Inocuidad Alimentaria (LANIIA), Centro de Investigación en Alimentación y Desarrollo (CIAD), Culiacán 80110, Sinaloa, Mexico; jose.aguirre@ciad.mx (J.R.A.-S.); chaqui@ciad.mx (C.C.-Q.) | |
| 245 | 1 | |a Genetic Characterization of <i>Staphylococcus aureus</i> Isolates Associated with Toxic Shock Syndrome Toxin Production: An Epidemiological and Bioinformatics Approach | |
| 260 | |b MDPI AG |c 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Staphylococcus aureus is an opportunistic pathogen, a member of the ESKAPE group, associated with nosocomial infections and foodborne illnesses due to its production of various toxins. This study conducted a comprehensive genomic characterization of S. aureus isolates producing toxic shock syndrome toxin (TSST-1) using a comparative genomics and bioinformatics approach. A total of 166, including 3 bovine mastitis isolates and 163 public genomes, were analyzed. Twenty-eight distinct sequence types (STs) were identified, with ST30 and ST5 being the most prevalent, corresponding to the clonal complexes CC30 and CC5, respectively. Phylogenetic reconstruction revealed two major clades aligned with these complexes, each exhibiting unique virulence factor profiles. Notably, TSST-1 was detected in bovine mastitis genomes, alongside a broad repertoire of virulence markers, such as enterotoxins and secretion system components, posing a potential risk to public health. Additionally, genes related to environmental information processing systems, including ABC transporters and phosphotransferase systems, were prevalent. These results underscore the need for strengthened genomic surveillance and the implementation of both preventive and corrective measures in dairy herds to mitigate zoonotic transmission and ensure food safety. | |
| 651 | 4 | |a Mexico | |
| 653 | |a Environmental information | ||
| 653 | |a Virulence factors | ||
| 653 | |a Epidemiology | ||
| 653 | |a Nosocomial infection | ||
| 653 | |a Bioinformatics | ||
| 653 | |a Cytokines | ||
| 653 | |a Dairy industry | ||
| 653 | |a Staphylococcus infections | ||
| 653 | |a Septic shock | ||
| 653 | |a Genomes | ||
| 653 | |a Genomics | ||
| 653 | |a Virulence | ||
| 653 | |a Foodborne diseases | ||
| 653 | |a Opportunist infection | ||
| 653 | |a Proteins | ||
| 653 | |a Public health | ||
| 653 | |a Cattle | ||
| 653 | |a Information processing | ||
| 653 | |a Food safety | ||
| 653 | |a Enterotoxins | ||
| 653 | |a Toxins | ||
| 653 | |a Pathogens | ||
| 653 | |a Data processing | ||
| 653 | |a Phylogenetics | ||
| 653 | |a Food contamination & poisoning | ||
| 653 | |a Biofilms | ||
| 653 | |a Phosphotransferase | ||
| 653 | |a Toxic shock syndrome | ||
| 653 | |a Gram-positive bacteria | ||
| 653 | |a Genes | ||
| 653 | |a Staphylococcal enterotoxin F | ||
| 653 | |a Mastitis | ||
| 653 | |a ABC transporters | ||
| 653 | |a Nosocomial infections | ||
| 653 | |a Epidemics | ||
| 653 | |a Economic | ||
| 653 | |a Staphylococcus aureus | ||
| 700 | 1 | |a Chaidez-Quiroz, C |u Laboratorio Nacional para la Investigación en Inocuidad Alimentaria (LANIIA), Centro de Investigación en Alimentación y Desarrollo (CIAD), Culiacán 80110, Sinaloa, Mexico; jose.aguirre@ciad.mx (J.R.A.-S.); chaqui@ciad.mx (C.C.-Q.) | |
| 700 | 1 | |a Castro-del Campo Nohemi |u Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Sinaloa, Blvd. San Angel 3886, Mercado de Abastos, San Benito, Culiacán 80260, Sinaloa, Mexico; ncastro@uas.edu.mx | |
| 700 | 1 | |a Castro-del, Campo Nohelia |u Laboratorio Nacional para la Investigación en Inocuidad Alimentaria (LANIIA), Centro de Investigación en Alimentación y Desarrollo (CIAD), Culiacán 80110, Sinaloa, Mexico; jose.aguirre@ciad.mx (J.R.A.-S.); chaqui@ciad.mx (C.C.-Q.) | |
| 773 | 0 | |t Toxins |g vol. 17, no. 9 (2025), p. 440-453 | |
| 786 | 0 | |d ProQuest |t Health & Medical Collection | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3254652528/abstract/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text + Graphics |u https://www.proquest.com/docview/3254652528/fulltextwithgraphics/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3254652528/fulltextPDF/embedded/7BTGNMKEMPT1V9Z2?source=fedsrch |