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Korsmeyer–Peppas Model for Diacetylaminoazotoluene (Dimazon) Release from PVA Foils: A Spectral Study

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Publicado no:Symmetry vol. 17, no. 10 (2025), p. 1739-1753
Autor principal: Gasner, Paul
Outros Autores: Babusca Daniela, Vleoanga Andrei, Dorohoi, Dana Ortansa
Publicado em:
MDPI AG
Assuntos:
Polymers
Toxicity
Diuretics
Experiments
Epithelium
Ulcers
Calibration
Solvents
Edema
Anisotropy
Medical equipment
Molecular weight
Foils
Drug dosages
Ethanol
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Resumo:Dimazon is known to stimulate the proliferation of epithelial cells. The dimazon released from locally attached polymer foils could be efficient for the treatment of skin damage. So, knowledge on the characteristics of the dimazon released from polymer matrices is important in establishing the continuous and predictable delivery of drug to a target. The spectrum of dimazon released from PVA foils is analysed based on the empirical Korsmeyer–Peppas model. The influence of the drug’s concentration and the film’s anisotropy, induced by stretching, on the delivery mechanism is highlighted. The results of this study could help clinical researchers establish a protocol for using dimazon from PVA foils in skin therapy.
ISSN:2073-8994
DOI:10.3390/sym17101739
Fonte:Engineering Database