প্রচ্ছদ

Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study

সংরক্ষণ করুন:
প্রকাশিত:Psychological Medicine vol. 55 (Oct 2025)
প্রধান লেখক: Hyat, Mahnoor
অন্যান্য লেখক: Zhu, Jinhan, Boltz, Toni A., Conomos, Matthew P., Hughes, Dylan E., Fohner, Alison E., Foster, Katherine T., Bigdeli, Tim B., Forsyth, Jennifer K.
প্রকাশিত:
Cambridge University Press
বিষয়গুলি:
United States > US
Genealogy
Accuracy
Cognition
Psychopathology
Schizophrenia
Mental disorders
Risk assessment
Families & family life
Affective disorders
Standard scores
Environmental aspects
Externalizing problems
Child Behavior Checklist
Aggressive behavior
Child development
Psychosis
Mental depression
Associations
Cognitive development
Internalization
Psychotic symptoms
Cognitive-behavioral factors
Intellectual development
Emotional behavior
Generalizability
Children & youth
Behavior
Emotional disorders
Childhood
Youth
Brain
Behavior problems
Children
Liability
Genetics
Adolescent development
Disorders
Symptoms
অনলাইন ব্যবহার করুন:Citation/Abstract
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সার সংক্ষেপ:Background Subtle behavioral and cognitive symptoms precede schizophrenia (SCZ) and appear in individuals with elevated risk based on polygenic risk scores (SCZ-PRS) and family history of psychosis (SCZ-FH). However, most SCZ-PRS studies focus on European ancestry youth, limiting generalizability. Furthermore, it remains unclear whether SCZ-FH reflects common-variant polygenic risk or broader SCZ liability. Methods Using baseline data from the Adolescent Brain Cognitive Development (ABCD) study, we investigated associations of SCZ-FH and SCZ-PRS with cognitive, behavioral, and emotional measures from NIH-Toolbox, Child Behavior Checklist (CBCL), and Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) for 9,636 children (mean age&#xa0;=&#xa0;9.92&#xa0;yrs, 47.4% female), specifically, 5,636 European, 2,093 African, and 1,477 Admixed American ancestry individuals. Results SCZ-FH was associated with SCZ-PRS (b&#xa0;=&#xa0;0.05, FDR-p&#xa0;=&#xa0;0.02) and subthreshold psychotic symptoms (b&#xa0;=&#xa0;0.46, FDR-p&#xa0;=&#xa0;0.01) in European youth, higher CBCL scores (b range&#xa0;=&#xa0;0.36–0.6, FDR-p&#xa0;<&#xa0;0.001), and higher odds of multiple internalizing and externalizing disorders (OR&#xa0;=&#xa0;1.10–1.22, FDR-p&#xa0;<&#xa0;0.001) across ancestries. SCZ-PRS was associated with lower cognition across ancestries (b&#xa0;=&#xa0;−0.43, FDR-p&#xa0;=&#xa0;0.02), higher CBCL total problems, anxious/depressed, rule-breaking and aggressive behaviors in European youth (b range&#xa0;=&#xa0;0.16–0.33, FDR-p&#xa0;<&#xa0;0.04), and depressive disorders in Admixed American youth (OR&#xa0;=&#xa0;1.37, FDR-p&#xa0;=&#xa0;0.02). Results remained consistent when SCZ-PRS and SCZ-FH were jointly modeled. Some SCZ-FH associations weakened when income-to-needs was accounted for, suggesting that SCZ-FH may capture both genetic and environmental influences. Conclusions SCZ-FH showed associations with broad psychopathology, while SCZ-PRS was associated with cognition and specific symptoms in European youth. Findings highlight their complementary role in SCZ risk assessment and the need to improve PRS utility across ancestries.
আইএসএসএন:0033-2917
1469-8978
ডিওআই:10.1017/S0033291725102304
সম্পদ:Sociology Database