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Belt-type electrical muscle stimulation preserves muscle fiber size but does not improve muscle function in a rat model of cancer cachexia

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Argitaratua izan da:PLoS One vol. 20, no. 11 (Nov 2025), p. e0336391
Egile nagusia: Kouzaki, Karina
Beste egile batzuk: Isemura, Mako, Tamura, Yuki, Uno, Hiroyuki, Tadano, Shunta, Akimoto, Ryuji, Hosoki, Katsu, Nakazato, Koichi
Argitaratua:
Public Library of Science
Gaiak:
Tohoku University
Japan
Ankle
Cancer
Protein synthesis
Hepatoma
Recovery of function
Animals
Chronic illnesses
Muscles
Protein folding
Muscle strength
Neuromuscular electrical stimulation
Protein biosynthesis
Proteins
Atrophy
Torque
Injection
Ascites
Musculoskeletal system
Skeletal muscle
Body fat
Stimulation
Muscle function
Puromycin
Cachexia
Chronic effects
Rodents
Social
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Laburpena:Cancer cachexia causes severe muscle wasting, and current treatments remain limited. Belt-type electrical muscle stimulation (bEMS) has emerged as a passive rehabilitation tool capable of activating multiple lower limb muscles simultaneously. We investigated whether bEMS prevents muscle wasting and improves functional outcomes in rats with cancer cachexia. Cancer cachexia was induced in male Sprague-Dawley rats by intraperitoneal injection of AH130 Yoshida hepatoma cells. Acute and chronic effects of bEMS were tested. Muscle protein synthesis was evaluated using the SUnSET method, and muscle fiber cross-sectional area (CSA) and ankle torque were measured after chronic stimulation. bEMS increased puromycin-labeled protein levels on day 3 post-injection (~1.5–2.0 fold; p < 0.05). After 10 days, bEMS mitigated reductions in muscle CSA in the gastrocnemius and tibialis anterior compared to the cachexia group. However, muscle strength (ankle torque) was not significantly improved. bEMS preserved muscle fiber size in cancer cachexia but failed to restore muscle function. These findings suggest bEMS may serve as a supportive strategy against muscle atrophy in cachectic conditions.
ISSN:1932-6203
DOI:10.1371/journal.pone.0336391
Baliabidea:Health & Medical Collection