Central nervous system and immune cells interactions in cancer: unveiling new therapeutic avenues
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| Yayımlandı: | Frontiers in Immunology vol. 16 (Feb 2025), p. 1528363-1528383 |
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| Diğer Yazarlar: | , , |
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Frontiers Media SA
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| Online Erişim: | Citation/Abstract Full Text Full Text - PDF |
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| Özet: | Cancer remains a leading cause of mortality worldwide. Despite significant advancements in cancer research, our understanding of its complex developmental pathways remains inadequate. Recent research has clarified the intricate relationship between the central nervous system (CNS) and cancer, particularly how the CNS influences tumor growth and metastasis via regulating immune cell activity. The interactions between the central nervous system and immune cells regulate the tumor microenvironment via various signaling pathways, cytokines, neuropeptides, and neurotransmitters, while also incorporating processes that alter the tumor immunological landscape. Furthermore, therapeutic strategies targeting neuro-immune cell interactions, such as immune checkpoint inhibitors, alongside advanced technologies like brain-computer interfaces and nanodelivery systems, exhibit promise in improving treatment efficacy. This complex bidirectional regulatory network significantly affects tumor development, metastasis, patient immune status, and therapy responses. Therefore, understanding the mechanisms regulating CNS-immune cell interactions is crucial for developing innovative therapeutic strategies. This work consolidates advancements in CNS-immune cell interactions, evaluates their potential in cancer treatment strategies, and provides innovative insights for future research and therapeutic approaches. |
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| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2025.1528363 |
| Kaynak: | Health & Medical Collection |