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Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases

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Veröffentlicht in:Animal Cells and Systems vol. 29, no. 1 (Dec 2025), p. 446-469
1. Verfasser: Han, Dongju
Weitere Verfasser: Lim, Younghyun, Lee, Soah, Seong-il Eyun
Veröffentlicht:
Taylor & Francis Ltd.
Schlagworte:
Troponin I
Calcium
Muscular function
Filaments
Muscles
Phosphorylation
Skeletal muscle
Actin
Actomyosin
Mutation
Muscle contraction
Structure-function relationships
Critical components
Cardiac muscle
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Abstract:ABSTRACT The troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle. Troponin I, a subunit of this complex, inhibits actomyosin interactions during muscle relaxation. Its function is finely tuned by posttranslational modifications, particularly phosphorylation, which influence calcium sensitivity and actin affinity, thus impacting muscle contraction. Mutations in troponin I are closely associated with various human diseases. Specifically, several mutations in cardiac troponin I have been linked to cardiomyopathies, such as hypertrophic, dilated, and restrictive cardiomyopathies, which affect heart contractility and calcium handling. In this review, we explore the multifaceted aspects of troponin I, including its structure, functional role in muscle contraction, evolution, and the complex interactions between posttranslational modifications and genetic mutations that alter its function and contribute to disease progression.
ISSN:1976-8354
2151-2485
1226-5071
1738-6357
DOI:10.1080/19768354.2025.2533821
Quelle:Biological Science Database