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First Insights into the Anti-Inflammatory Potential of Colliguaja odorifera Molina Leaf Extracts and Their Isolated Phenolic Compounds

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Pubblicato in:Plants vol. 14, no. 24 (2025), p. 3839-3855
Autore principale: Figueroa, Amy
Altri autori: Mutis, Ana, Hormazabal Emilio, Rubilar Olga, Hermosilla, Edward, Lago João Henrique Ghilardi, Quiroz Andrés, Espinoza, Javier
Pubblicazione:
MDPI AG
Soggetti:
Chile
Mass spectrometry
Traditional medicine
Butanol
Anti-inflammatory agents
Acids
Lipoxygenase
Shikimic acid
Phenols
Leaves
Liquid oxygen
Metabolites
Chromatography
Magnetic resonance spectroscopy
Drug development
Ethyl acetate
Nonsteroidal anti-inflammatory drugs
Analgesics
Inflammation
Gallic acid
Chemical composition
NMR spectroscopy
Secondary metabolites
Mass spectroscopy
Plant extracts
Acetic acid
Enzymes
Phospholipase A2
Cultural heritage
Phenolic compounds
Colliguaja odorifera
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Abstract:Despite the ethnobotanical significance of Chilean Colliguaja species, research on their biological activities and phytochemical composition remains limited. Among these species, Colliguaja odorifera Molina (Euphorbiaceae), traditionally used in folk medicine to alleviate toothaches, stands out for its potential for medicinal applications. This study aims to investigate the anti-inflammatory activity of the C. odorifera leaf extracts and their secondary metabolites isolated from the most active extract. A hydroalcoholic extract of C. odorifera leaves was prepared, and subsequently ethyl acetate (EA-E), n-butanol (B-E), and water (W-E) extracts were obtained by liquid–liquid partition. The extracts were first evaluated for their ability to inhibit lipoxygenase, and the most active extract was subsequently tested for hyaluronidase (HA) and secretory phospholipase A2 (sPLA2). The most active extract was EA-E, with IC50 values of 11.75, 31.09, and 6.60 µg/mL for anti-LOX activity, hyaluronidase, and sPLA2, respectively. This extract was analyzed by chromatography coupled to mass spectrometry and 1H and 13C NMR spectroscopy, allowing the identification, for the first time, of shikimic acid, gallic acid, methyl gallate, ethyl gallate, and a putative galloyl-luteolin. These results suggest that C. odorifera is a promising candidate for the development of natural alternatives to nonsteroidal anti-inflammatory drugs.
ISSN:2223-7747
DOI:10.3390/plants14243839
Fonte:Agriculture Science Database