Characterizing the contribution of alcohol use towards neuropsychological profiles in mild cognitive impairment
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| Publicat a: | Alzheimer's & Dementia vol. 21 (Dec 1, 2025) |
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| Altres autors: | , , , , , , , , , , , , |
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John Wiley & Sons, Inc.
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| Accés en línia: | Citation/Abstract Full Text - PDF |
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| 001 | 3286416819 | ||
| 003 | UK-CbPIL | ||
| 022 | |a 1552-5260 | ||
| 022 | |a 1552-5279 | ||
| 024 | 7 | |a 10.1002/alz70857_100017 |2 doi | |
| 035 | |a 3286416819 | ||
| 045 | 0 | |b d20251201 | |
| 100 | 1 | |a Cuperfain, Ari |u University of Toronto Temerty Faculty of Medicine, Toronto, ON, Canada, | |
| 245 | 1 | |a Characterizing the contribution of alcohol use towards neuropsychological profiles in mild cognitive impairment | |
| 260 | |b John Wiley & Sons, Inc. |c Dec 1, 2025 | ||
| 513 | |a Journal Article | ||
| 520 | 3 | |a Background Excessive alcohol use is known to increase the risk of dementia, however, how alcohol specifically effects cognition in patients with neurocognitive disorders is unclear. In this study, we characterized the effects of excessive alcohol use on cognitive domains in those with mild cognitive impairment (MCI). Method Two multicenter cohorts, the Comprehensive Assessment of Neurodegeneration and Dementia and the Ontario Neurodegenerative Disease Research Initiative, provided data for this study. Participants were diagnosed with MCI due to Alzheimer's disease (AD‐MCI) or cerebro‐vascular disease (V‐MCI), and were categorized based on their current and past alcohol use into ‘zero’, ‘low‐medium’ (less than 1 to 7 standard drinks/week), or ‘high’ (>7 standard drinks/week) alcohol use groups. We generated age‐corrected composite cognitive domain scores for Processing Speed, Memory Encoding, Recall and Recognition, Executive Control, Executive Function, Visuoperceptual, and Language domains, and compared them among the three groups while controlling for sex, pre‐morbid intelligence, and diagnosis. Result The zero alcohol group included 157 participants (females = 48.4%; V‐MCI = 52.2%) with mean (SD) age 71.26 (6.93) years, the low‐medium alcohol group included 213 participants (females = 42.2%; V‐MCI = 44.1%) with mean (SD) age 71.64 (7.77) years, and the high alcohol group included 73 participants (females = 20.5%; V‐MCI = 50.1%) with mean (SD) age 72.23 (7.51) years. The groups differed only in Processing Speed (F(2,407) = 3.298, p =  0.038), Memory Encoding (F(2,394) = 4.689, p =  0.010) and Recall (F(2,403) = 3.997, p =  0.019). Pairwise comparisons revealed a significant difference between the low‐medium and high alcohol groups in both Memory Encoding (p = 0.019) and Recall (p = 0.018), with participants in the high alcohol group demonstrating lower performance. There were no differences between the zero alcohol group and other groups. There were no pairwise differences for Processing Speed. Conclusion In participants with AD‐MCI or V‐MCI, excessive alcohol use is associated with worse memory encoding and retrieval, but not retention. This is consistent with a more dysexecutive memory profile than a typical amnestic cognitive profile. Future studies should investigate underlying mechanisms for these deficits, and their impact on prognosis of the illness. | |
| 653 | |a Neurocognition | ||
| 653 | |a Alcohol use | ||
| 653 | |a Groups | ||
| 653 | |a Memory | ||
| 653 | |a Medical diagnosis | ||
| 653 | |a Age | ||
| 653 | |a Dementia | ||
| 653 | |a Females | ||
| 653 | |a Executive control | ||
| 653 | |a Cognition | ||
| 653 | |a Neuropsychology | ||
| 653 | |a Cognitive ability | ||
| 653 | |a Cognitive impairment | ||
| 653 | |a Intoxication | ||
| 653 | |a Recall | ||
| 653 | |a Encoding | ||
| 653 | |a Drinks | ||
| 653 | |a Patients | ||
| 653 | |a Alzheimer's disease | ||
| 653 | |a Medical prognosis | ||
| 653 | |a Age groups | ||
| 653 | |a Encoding (Cognitive process) | ||
| 653 | |a Retrieval | ||
| 653 | |a Intelligence | ||
| 653 | |a Disorders | ||
| 653 | |a Vascular disease | ||
| 653 | |a Executive function | ||
| 653 | |a Disease | ||
| 653 | |a Profiles | ||
| 700 | 1 | |a Pishdadian, Sara |u Centre for Addiction and Mental Health, Toronto, ON, Canada, | |
| 700 | 1 | |a Binns, Malcolm A |u Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, | |
| 700 | 1 | |a Black, Sandra E. |u Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, | |
| 700 | 1 | |a Chertkow, Howard |u Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, | |
| 700 | 1 | |a Freedman, Morris |u Baycrest Health Sciences, Toronto, ON, Canada, | |
| 700 | 1 | |a Louis, Janine |u Centre for Addiction and Mental Health, Toronto, ON, Canada, | |
| 700 | 1 | |a Ma, Clement |u Centre for Addiction and Mental Health, Toronto, ON, Canada, | |
| 700 | 1 | |a Masellis, Mario |u Sunnybrook Health Sciences Centre, Toronto, ON, Canada, | |
| 700 | 1 | |a McLaughlin, Paula M |u Nova Scotia Health, Halifax, NS, Canada, | |
| 700 | 1 | |a Ramirez, Joel |u Sunnybrook Health Sciences Centre, Toronto, ON, Canada, | |
| 700 | 1 | |a Tang‐Wai, David F. |u Krembil Brain Institute, University Health Network (UHN), Toronto, ON, Canada, | |
| 700 | 1 | |a Tartaglia, Carmela |u Krembil Brain Institute, University Health Network (UHN), Toronto, ON, Canada, | |
| 700 | 1 | |a Kumar, Sanjeev |u Centre for Addiction and Mental Health, Toronto, ON, Canada, | |
| 773 | 0 | |t Alzheimer's & Dementia |g vol. 21 (Dec 1, 2025) | |
| 786 | 0 | |d ProQuest |t Consumer Health Database | |
| 856 | 4 | 1 | |3 Citation/Abstract |u https://www.proquest.com/docview/3286416819/abstract/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |
| 856 | 4 | 0 | |3 Full Text - PDF |u https://www.proquest.com/docview/3286416819/fulltextPDF/embedded/L8HZQI7Z43R0LA5T?source=fedsrch |