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Applicability of the CANTAB-PAL Computerized Memory Test in Identifying Amnestic Mild Cognitive Impairment and Alzheimer's Disease

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Gepubliceerd in:Dementia and Geriatric Cognitive Disorders vol. 34, no. 2 (Sep 2012), p. 83-89
Hoofdauteur: Junkkila, Jenny
Andere auteurs: Oja, Sakari, Laine, Matti, Karrasch, Mira
Gepubliceerd in:
S. Karger AG
Onderwerpen:
Aged
Aged, 80 & over
Alzheimer Disease > diagnosis
Case-Control Studies
Discriminant Analysis
Female
Humans
Male
Middle Aged
Mild Cognitive Impairment > diagnosis
Neuropsychological Tests
Paired-Associate Learning
Aging
Recall
Delayed
Cognitive impairment
Learning
Delayed recall
Errors
Word lists
Memory
Educational activities
Medical screening
Computerization
Tests
Alzheimer's disease
Paired associate learning
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Samenvatting:Aim: To compare the diagnostic accuracy of a computerized test, the CANTAB paired associate learning (PAL) to that of an established and validated noncomputerized test, the CERAD Wordlist Learning task in differentiating between normal aging, aMCI and AD in a cross-sectional design. Methods: 58 participants were assessed (19 with mild probable AD, 17 aMCI, 22 healthy controls). Results: The variables found to best discriminate between the three groups were the CANTAB PAL total errors adjusted (p < 0.0001, 81.0% of the cases correctly classified), and CERAD Wordlist Learning Delayed Recall (p < 0.0001, 77.6% of the cases correctly classified). Using both PAL total errors adjusted and Wordlist Learning Delayed Recall, 84.5% of the cases were correctly classified. Discussion: The results suggest that the CANTAB could be used for screening of AD-typical memory impairment. Copyright © 2012 S. Karger AG, Basel [PUBLICATION ABSTRACT]   To compare the diagnostic accuracy of a computerized test, the CANTAB paired associate learning (PAL) to that of an established and validated noncomputerized test, the CERAD Wordlist Learning task in differentiating between normal aging, aMCI and AD in a cross-sectional design. 58 participants were assessed (19 with mild probable AD, 17 aMCI, 22 healthy controls). The variables found to best discriminate between the three groups were the CANTAB PAL total errors adjusted (p < 0.0001, 81.0% of the cases correctly classified), and CERAD Wordlist Learning Delayed Recall (p < 0.0001, 77.6% of the cases correctly classified). Using both PAL total errors adjusted and Wordlist Learning Delayed Recall, 84.5% of the cases were correctly classified. The results suggest that the CANTAB could be used for screening of AD-typical memory impairment.
ISSN:1420-8008
1421-9824
1013-7424
DOI:10.1159/000342116
Bron:Science Database