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Phylogenetic methods come of age: Testing hypotheses in an evolutionary context

Kaydedildi:
Yayımlandı:Science vol. 276, no. 5310 (Apr 11, 1997), p. 227-232
Yazar: Huelsenbeck, John P
Diğer Yazarlar: Rannala, Bruce
Baskı/Yayın Bilgisi:
The American Association for the Advancement of Science
Konular:
Evolution
Evolution, Molecular
Phylogeny
Molecules
Simulation
Biology
Biologists
Parasites
Deoxyribonucleic acid > DNA
Computer Simulation
Mathematical Models
Communicable Diseases
Probability
Topology
Hypothesis Testing
Monte Carlo Methods
Maximum Likelihood Statistics
Environmental
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Özet:The use of molecular phylogenies to examine evolutionary questions has become commonplace with the automation of DNA sequencing and the availability of efficient computer programs to perform phylogenetic analyses. The application of computer simulation and likelihood ratio tests to evolutionary hypotheses represents a recent methodological development in this field. Likelihood ratio tests have enabled biologists to address many questions in evolutionary biology that have been difficult to resolve in the past, such as whether host-parasite systems are cospeciating and whether models of DNA substitution adequately explain observed sequences.
ISSN:0036-8075
1095-9203
Kaynak:Science Database