Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation
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| 出版年: | Molecules vol. 30, no. 4 (2025), p. 788 |
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| 第一著者: | |
| その他の著者: | , , , |
| 出版事項: |
MDPI AG
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| 主題: | |
| オンライン･アクセス: | Citation/Abstract Full Text + Graphics Full Text - PDF |
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| 抄録: | Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in the skin. Tyrosinase, the rate-limiting enzyme in melanin biosynthesis, is a crucial enzyme in melanin synthesis. However, existing tyrosinase inhibitors pose some degree of toxicity to humans. Therefore, the development of more efficient and low-toxicity tyrosinase inhibitors is urgently needed. This review briefly depicts the melanin biosynthesis process and the crystal structure and catalytic mechanism of tyrosinase. The latest research progress regarding small-molecule tyrosinase inhibitors is also reviewed. Moreover, the structure–function relationships are analyzed and summarized. This is expected to provide new and more scientific insights to enable researchers to explore safer and more potent tyrosinase inhibitors. |
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| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules30040788 |
| ソース: | Health & Medical Collection |