Effects of Transcranial Pulse Stimulation of the Primary Motor Cortex on Motor Performance in Healthy Adults: A Randomized Crossover Pilot Study
I tiakina i:
| I whakaputaina i: | CNS Neuroscience & Therapeutics vol. 31, no. 12 (Dec 1, 2025) |
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| Kaituhi matua: | |
| Ētahi atu kaituhi: | , , , , , , , , , |
| I whakaputaina: |
John Wiley & Sons, Inc.
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| Ngā marau: | |
| Urunga tuihono: | Citation/Abstract Full Text Full Text - PDF |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| Whakarāpopotonga: | ABSTRACT Aims We aimed to investigate the behavioral aftereffects of a novel noninvasive brain stimulation technique—transcranial pulse stimulation (TPS)—applied over the right motor cortex (rM1) in healthy adults. Methods Thirty‐four healthy adults underwent a randomized, subject‐ and analyst‐ blind, crossover trial, receiving active TPS over the rM1 or control TPS over the vertex in two sessions 24 h apart. Motor performance was assessed using the Nine‐Hole Peg Test (NHPT) and the Simple Reaction Time Task (SRTT) before, immediately after, and every 10 min for 40 min after each session. A linear mixed model and post hoc analyses were applied to evaluate the effects. Results No significant interaction effect (stimulation condition × time) was found. The left‐hand NHPT performance significantly improved from 10 min post‐TPS onward in both conditions (ps ≤ 0.002). Conclusion A single session of rM1‐TPS does not yield significant improvements in motor dexterity compared to vertex‐TPS. Future well‐powered studies with a sham control condition and multiple stimulation sessions are needed to investigate the aftereffects using a combination of neurophysiological and neuroimaging approaches. Trial Registration This study was registered in ClinicalTrial.gov in April 2024 (NCT06312930) |
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| ISSN: | 1755-5930 1755-5949 1080-563X |
| DOI: | 10.1002/cns.70711 |
| Puna: | Health & Medical Collection |