(Unlearned) lessons from John Graunt and Kenneth Rothman: A "CLASSic" example

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Bibliographische Detailangaben
Veröffentlicht in:	Clinical Therapeutics vol. 25, no. 11 (Nov 2003), p. 2891
1. Verfasser:	Arellano, Felix M.
Körperschaft:	Class
Weitere Verfasser:	Castellsague, Jordi
Veröffentlicht:	Elsevier Limited
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal > adverse effects Data Interpretation, Statistical Endpoint Determination Epidemiologic Methods Epidemiologic Research Design Humans Peptic Ulcer > chemically induced Randomized Controlled Trials as Topic
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Beschreibung
Abstract:	This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Lonngterm Arthritis Safety Study. This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Long-term Arthritis Safety Study.
ISSN:	0149-2918 1879-114X
DOI:	10.1016/S0149-2918(03)80341-7
Quelle:	Healthcare Administration Database