(Unlearned) lessons from John Graunt and Kenneth Rothman: A "CLASSic" example

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التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Clinical Therapeutics vol. 25, no. 11 (Nov 2003), p. 2891
المؤلف الرئيسي:	Arellano, Felix M.
مؤلف مشترك:	Class
مؤلفون آخرون:	Castellsague, Jordi
منشور في:	Elsevier Limited
الموضوعات:	Anti-Inflammatory Agents, Non-Steroidal > adverse effects Data Interpretation, Statistical Endpoint Determination Epidemiologic Methods Epidemiologic Research Design Humans Peptic Ulcer > chemically induced Randomized Controlled Trials as Topic
الوصول للمادة أونلاين:	Citation/Abstract Full Text Full Text - PDF
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

الوصف
مستخلص:	This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Lonngterm Arthritis Safety Study. This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Long-term Arthritis Safety Study.
تدمد:	0149-2918 1879-114X
DOI:	10.1016/S0149-2918(03)80341-7
المصدر:	Healthcare Administration Database