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(Unlearned) lessons from John Graunt and Kenneth Rothman: A "CLASSic" example

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Publicado no:Clinical Therapeutics vol. 25, no. 11 (Nov 2003), p. 2891
Autor principal: Arellano, Felix M.
Autor Corporativo: Class
Outros Autores: Castellsague, Jordi
Publicado em:
Elsevier Limited
Assuntos:
Anti-Inflammatory Agents, Non-Steroidal > adverse effects
Data Interpretation, Statistical
Endpoint Determination
Epidemiologic Methods
Epidemiologic Research Design
Humans
Peptic Ulcer > chemically induced
Randomized Controlled Trials as Topic
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Resumo:  This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Lonngterm Arthritis Safety Study.   This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Long-term Arthritis Safety Study.
ISSN:0149-2918
1879-114X
DOI:10.1016/S0149-2918(03)80341-7
Fonte:Healthcare Administration Database