(Unlearned) lessons from John Graunt and Kenneth Rothman: A "CLASSic" example

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Podrobná bibliografie
Vydáno v:	Clinical Therapeutics vol. 25, no. 11 (Nov 2003), p. 2891
Hlavní autor:	Arellano, Felix M.
Korporativní autor:	Class
Další autoři:	Castellsague, Jordi
Vydáno:	Elsevier Limited
Témata:	Anti-Inflammatory Agents, Non-Steroidal > adverse effects Data Interpretation, Statistical Endpoint Determination Epidemiologic Methods Epidemiologic Research Design Humans Peptic Ulcer > chemically induced Randomized Controlled Trials as Topic
On-line přístup:	Citation/Abstract Full Text Full Text - PDF
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Popis
Abstrakt:	This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Lonngterm Arthritis Safety Study. This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Long-term Arthritis Safety Study.
ISSN:	0149-2918 1879-114X
DOI:	10.1016/S0149-2918(03)80341-7
Zdroj:	Healthcare Administration Database